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Rekombinant Anti-E2F4 Antikörper [E2F4/8811R] (A314903)

$765

Monoklonal [E2F4/8811R] Kaninchen Antikörper gegen E2F4 für IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Versandkosten
Vorlaufzeit
Lieferung in 4-6 Werktagen
Telefon
+1 (314) 370-6046
Mo bis Frei, 8am - 4pm AST
Email
orders@antibodies.com
Produktname
Anti-E2F4 Antibody [E2F4/8811R]
Beschreibung
Recombinant rabbit monoclonal [E2F4/8811R] antibody to E2F4.
Spezifität
The human retinoblastoma gene product appears to play an important role in the negative regulation of cell proliferation. Functional inactivation of Rb can be mediated either through mutation or as a consequence of interaction with DNA tumor virus-encoded proteins. Of all the Rb associations described to date, the identification of a complex between Rb and the transcription factor E2F most directly implicates Rb in regulation of cell proliferation. E2F was originally identified through its role in transcriptional activation of the adenovirus E2 promoter. Sequences homologous to the E2F binding site have been found upstream of a number of genes that encode proteins with putative functions in the G1 and S phases of the cell cycle. E2F-1 is a member of a broader family of transcription regulators including E2F-2, E2F-3, E2F-4, E2F-5, E2F-6 and E2F-7 each of which forms heterodimers with a second protein, DP-1, forming an active E2F transcriptional regulatory complex.
Anwendungen
IHC-P
Positivkontrolle
Found in all tissue examined including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Verdünnungen
IHC: 1-2 µg/ml
Reaktivität
Human
Immunogen
Recombinant fragment (around Amino Acids 1-100) of human E2F4 protein. The exact sequence is proprietary.
Wirt
Rabbit
Klonalität
Monoclonal
Klon
E2F4/8811R
Isotyp
IgG
Leichte Ketten
kappa
Konjugat

Unconjugated

Reinigung
Protein A/G chromatography.
Konzentration
200 µg/ml
Molekulargewicht
60 kDa
Produktform
Liquid
Formulierung
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Lagerung
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyme
E2F 4, E2F transcription factor 4, E2F transcription factor 4 p107/p130 binding, E2F-4, E2F4_HUMAN, p107/p130 binding protein, Transcription factor E2F 4, Transcription factor E2F4
Isotyp-Kontrollantikörper
Haftungsausschluss
Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.

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