This antibody recognises human Tumor necrosis factor receptor superfamily member 21, also known as death domain containing receptor DR6, Death receptor 6 or CD358. DR6 is a 655 amino acid ~72 kDa type 1 single pass transmembrane glycoprotein with four extracellular cysteine rich repeats and a single cytoplasmic death domain. DR6 is widely expressed in human tissues and cell lines. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK.

Anwendungen

Verdünnungen

WB: 1:500

Reaktivität

Human

Immunogen

A peptide corresponding to amino acids 42-56 of human DR6 precursor.

Sequenz

QPEQKASNLIGTYRH

Wirt

Rabbit

Klonalität

Polyclonal

Isotyp

IgG

Konjugat

Unconjugated

Konzentration

500 µg/ml

Produktform

Liquid

Formulierung

Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.

Lagerung

Store undiluted at 4°C. Do not freeze! Should this product contain a precipitate we recommend microcentrifugation before use.

Allgemeine Hinweise

Rabbit anti Human DR6 antibody recognizes human Tumor necrosis factor receptor superfamily member 21, also known as death domain containing receptor DR6, Death receptor 6 or CD358. DR6 is a 655 amino acid ~72 kDa type 1 single pass transmembrane glycoprotein with four extracellular cysteine rich repeats and a single cytoplasmic death domain. DR6 is widely expressed in human tissues and cell lines. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK (Pan et al. 1998).

Synonyme

BM 018, BM018, CD358, Death receptor 6, DR 6, MGC31965, OTTHUMP00000039915, TNFR related death receptor 6, TNFRSF 21, TNFRSF21, TNFRSF21 protein, TNR21_HUMAN, Tumor necrosis factor receptor superfamily member 21, Tumor necrosis factor receptor superfamily member 21 precursor

Isotyp-Kontrollantikörper

Kompatible Sekundärantikörper

Haftungsausschluss

Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.