This antibody recognises disrupted in schizophrenia 1 (DISC1), ~93 kDa protein located in the nucleus, cytoplasm and mitochondria. The DISC1 protein is widely expressed in normal tissues. It is involved in neurite outgrowth and cortical development through its interaction with a variety of proteins including lissencephaly-1 (LIS1), NudeE-like (NUDEL) and phosphodiesterase 4B. In certain cases of schizophrenia the DISC1 gene has been found to be disrupted by a t(1;11) (q42.1;q14.3) translocation, and DISC1 could be a candidate susceptibility gene for this condition. Rabbit anti DISC1 antibody is suitable for immunocytochemistry (ICC) at a concentration of 5µg/ml.

Anwendungen

WB, IHC-Fr

Verdünnungen

WB: 1 - 2 µg/ml

Reaktivität

Human, Mouse

Immunogen

A peptide corresponding to 18 amino acids near the centre of human DISC1.

Wirt

Rabbit

Klonalität

Polyclonal

Isotyp

IgG

Konjugat

Unconjugated

Reinigung

Affinity chromatography.

Konzentration

1 mg/ml

Molekulargewicht

Approximately 95-100 kDa in SK-N-SH cell lysate.

Produktform

Liquid

Formulierung

Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.

Lagerung

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Allgemeine Hinweise

Rabbit anti DISC1 antibody recognizes disrupted in schizophrenia 1 (DISC1), ~93 kDa protein located in the nucleus, cytoplasm and mitochondria. The DISC1 protein is widely expressed in normal tissues. It is involved in neurite outgrowth and cortical development through its interaction with a variety of proteins including lissencephaly-1 (LIS1), NudeE-like (NUDEL) and phosphodiesterase 4B. In certain cases of schizophrenia the DISC1 gene has been found to be disrupted by a t(1;11) (q42.1;q14.3) translocation, and DISC1 could be a candidate susceptibility gene for this condition (Wang et al. 2018).Rabbit anti DISC1 antibody is suitable for immunocytochemistry (ICC) at a concentration of 5µg/ml.

Synonyme

C1orf136, DISC1_HUMAN, Disrupted in schizophrenia 1, Disrupted in schizophrenia 1 protein, KIAA0457, RP4-730B13.1, SCZD9

Isotyp-Kontrollantikörper

Kompatible Sekundärantikörper

Haftungsausschluss

Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.