Anti-Desmoglein 1 Antikörper [DSG1/1733] (A251550)

Anti-Desmoglein 1 Antibody [DSG1/1733] - BSA and Azide free

Mouse monoclonal [DSG1/1733] antibody to Desmoglein 1.

This antibody recognizes a protein of ~150kDa, identified as Desmoglein-1 (DSG1). Desmoglein-1 is a member of the desmosomal cadherin family.Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms.Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.

IHC-P

IHC-P: 1-2 µg/ml

Human

Recombinant fragment of human Desmoglein 1 protein; corresponding to intracellular domain.

Mouse

Monoclonal

DSG1/1733

IgG1

Unconjugated

Protein A/G chromatography.

1 mg/ml

150 kDa (precursor) / 160 kDa (mature)

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-Desmoglein 1 Antibody [DSG1/1733] (A248368).

Cadherin family member 4, CDHF4, Desmoglein-1, Desmosomal glycoprotein 1, DG1, DGI, DSG, DSG1, DSG1_HUMAN, EPKHE, EPKHIA, Pemphigus foliaceus antigen, PPKS1, SPPK1