Anti-delta 1 Catenin Antikörper [CTNND1/4501] (A277567)

Anti-delta 1 Catenin Antibody [CTNND1/4501]

Mouse monoclonal [CTNND1/4501] antibody to delta 1 Catenin.

Alpha-catenin and beta-catenin bind to the intracellular domain of E-cadherin while p120 catenin binds E-cadherin at a juxta-membrane site. The complex stabilizes tight junctions. In the cell, p120 catenin localized to the E-cadherin/catenins cell adhesion complex, directly associates with cytoplasmic C-terminus of E-cadherin and may similarly interact with other cadherins. p120 is a proliferation-associated nucleolar protein found in most human malignant tumors, but not in resting normal cells. In colorectal cancer the altered localization of p120 catenin corresponds with loss of cytoplasmic localization of E-cadherin. Studies have shown accurate categorization of ductal vs. lobular neoplasia in the breast was achieved with p120 staining. p120 expression further clarifies the separation of low-grade ductal carcinoma in situ from lobular neoplasia. Studies also have shown that altered expression of p120 catenin antibody predicts poor outcome in invasive breast cancer.

IHC-P

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 138-276, of human delta 1 Catenin. The exact sequence is proprietary.

Mouse

Monoclonal

CTNND1/4501

IgG2b

Unconjugated

Protein A/G chromatography.

200 µg/ml

120 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-delta 1 Catenin Antibody [CTNND1/4501] - BSA and Azide free (A278155).

Cadherin associated Src substrate, Cadherin-associated Src substrate, CAS, Catenin (cadherin associated protein) delta 1, Catenin delta, Catenin delta 1, Catenin delta-1, CTND1_HUMAN, CTNND, CTNND 1, CTNND1, KIAA0384, p120, P120 CAS, p120 catenin, P120 CTN, p120(cas), p120(ctn), P120CAS, P120CTN