Anti-CXCR4 Antikörper [9D9] (A279571)

Anti-CXCR4 Antibody [9D9]

Mouse monoclonal [9D9] antibody to CXCR4.

This antibody recognises the chicken homologue of human CD184, also known as CXCR4 (C-X-C Receptor type 4) and fusin.CXCR4 is a receptor for the chemokine, stromal-derived factor-1 (SDF-1), also known as CXCL12. Research has demonstrated that in chicks CXCR4 is expressed by cardiac neural crest cells and together with SDF-1 is involved with the migration of cells and development of the heart. Where CXCR4 function is lost, cell migration is impaired resulting in cell death and misexpression of SDF-1 leading to cardiovascular defects (Escot et al. 2013). CXCR4 expression is also linked with other development processes including cerebellar development and with vascularization of the gastrointestinal tract. Clone 9D9 provides a useful antibody for studying development biological processes.Bursa cells may be used as a positive control for CXCR4 in flow cytometry.

IF, Flow Cytometry, IHC-Fr

Use 10µl of the suggested working dilution to label 1x10⁶ cells in 100µl

Chicken

Chicken CXCR4 (chCXCR4) transfected HEK294 cells.

Mouse

Monoclonal

9D9

IgG2a

Unconjugated

Protein G affinity chromatography of tissue culture supernatant.

Liquid

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Chicken CD184 / CXCR4 clone 9D9, recognizes the chicken homologue of human CD184, also known as CXCR4 (C-X-C Receptor type 4) and fusin.CXCR4 is a receptor for the chemokine, stromal-derived factor-1 (SDF-1), also known as CXCL12. Research has demonstrated that in chicks CXCR4 is expressed by cardiac neural crest cells and together with SDF-1 is involved with the migration of cells and development of the heart. Where CXCR4 function is lost, cell migration is impaired resulting in cell death and misexpression of SDF-1 leading to cardiovascular defects (Escot et al. 2013). CXCR4 expression is also linked with other development processes including cerebellar development and with vascularization of the gastrointestinal tract. Clone 9D9 provides a useful antibody for studying development biological processes.Bursa cells may be used as a positive control for CXCR4 in flow cytometry.

C-X-C chemokine receptor type 4, CD184, CD184 antigen, Chemokine (C X C motif) receptor 4, Chemokine CXC Motif Receptor 4, CXC-R4, CXCR-4, CXCR4_HUMAN, D2S201E, FB22, Fusin, HM89, HSY3RR, LAP 3, LAP3, LCR1, LESTR, Leukocyte derived seven transmembrane domain receptor, Leukocyte-derived seven transmembrane domain receptor, Lipopolysaccharide associated protein 3, Neuropeptide Y receptor Y3, NPY3R, NPYR, NPYRL, NPYY3, NPYY3R, Probable G protein coupled receptor lcr1 homolog, SDF 1 receptor, SDF-1 receptor, SEVEN-TRANSMEMBRANE-SEGMENT RECEPTOR, Stromal cell derived factor 1 receptor, Stromal cell-derived factor 1 receptor, WHIM, WHIMS