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Anti-CTLA4 Antikörper [1B8] (A279084)

$340

Monoklonal [1B8] Hamster Antikörper gegen CTLA4 für WB, IP, Flow Cytometry, ELISA und IF.

Versandkosten
Vorlaufzeit
Lieferung in 4-6 Werktagen
Telefon
+1 (314) 370-6046
Mo bis Frei, 8am - 4pm AST
Email
orders@antibodies.com
Produktname
Anti-CTLA4 Antibody [1B8]
Beschreibung
Hamster monoclonal [1B8] antibody to CTLA4.
Spezifität
This antibody recognises mouse CD152, commonly known as CTLA-4 (cytotoxic T-lymphocyte protein 4), a structural homolog for CD28. CD152 binds the same ligands as CD28, namely CD80 (B7.1) and CD86 (B7.2), but with much higher affinity. However, while binding of CD28 enhances T cell function, binding of CD152 inhibits it. CD152 is not detected on naïve T-cells and is induced upon T-cell activation. In mice, lack of CD152 leads to massive lymphoproliferative disorder leading to tissue destruction and autoimmunity, suggesting a critical role for CD152 in limiting T-cell responses. CD152 has been shown to reduce IL-2 production after ligation and can inhibit T-cell expansion. This regulatory role and the high binding affinity of CD152 make it a potential therapy for autoimmune diseases such as rheumatoid arthritis. Hamster anti Mouse CD152 antibody, clone 1B8 may be used to enhance proliferation and pro-inflammatory cytokines of lymph node cells. It may also be used to enhance tumour immunity.
Anwendungen
WB, IP, Flow Cytometry, ELISA, IF
Verdünnungen
Flow Cytometry: 1:10 - 1:100, Use 10µl of the suggested working dilution to label 1x106 cells in 100µl.
Reaktivität
Mouse
Immunogen
Extracellular portion of mouse CD152 fused to a mouse IgG2a.
Wirt
Hamster
Klonalität
Monoclonal
Klon
1B8
Isotyp
IgG
Konjugat

Unconjugated

Reinigung
Protein G affinity chromatography of tissue culture supernatant.
Konzentration
1 mg/ml
Produktform
Liquid
Formulierung
Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.
Lagerung
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
Allgemeine Hinweise
Hamster anti Mouse CD152 antibody, clone 1B8 recognizes mouse CD152, commonly known as CTLA-4 (cytotoxic T-lymphocyte protein 4), a structural homolog for CD28. CD152 binds the same ligands as CD28, namely CD80 (B7.1) and CD86 (B7.2), but with much higher affinity. However, while binding of CD28 enhances T cell function, binding of CD152 inhibits it. CD152 is not detected on naïve T-cells and is induced upon T-cell activation. In mice, lack of CD152 leads to massive lymphoproliferative disorder leading to tissue destruction and autoimmunity, suggesting a critical role for CD152 in limiting T-cell responses. CD152 has been shown to reduce IL-2 production after ligation and can inhibit T-cell expansion. This regulatory role and the high binding affinity of CD152 make it a potential therapy for autoimmune diseases such as rheumatoid arthritis. Hamster anti Mouse CD152 antibody, clone 1B8 may be used to enhance proliferation and pro-inflammatory cytokines of lymph node cells. It may also be used to enhance tumour immunity.
Synonyme
ALPS5, CD, CD 152, CD152, CD152 antigen, CD152 isoform, Celiac disease 3, CELIAC3, CTLA 4, CTLA-4, CTLA4_HUMAN, Cytotoxic T cell associated 4, Cytotoxic T lymphocyte antigen 4, Cytotoxic T lymphocyte associated 4, Cytotoxic T lymphocyte associated 4, soluble isoform, included, Cytotoxic T lymphocyte associated antigen 4, Cytotoxic T lymphocyte associated antigen 4 short spliced form, Cytotoxic T lymphocyte associated protein 4, Cytotoxic T lymphocyte associated serine esterase 4, Cytotoxic T lymphocyte protein 4, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, GRD4, GSE, ICOS, IDDM12, insulin-dependent diabetes mellitus 12, Ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4, OTTHUMP00000216623
Haftungsausschluss
Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.

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