Recombinant human monoclonal [DS-9606a] antibody to Claudin 6.
Anwendungen
ELISA, FACS, Functional Assay, In Vivo
Reaktivität
Human
Wirt
Human
Klonalität
Monoclonal
Klon
DS-9606a
Isotyp
IgG1
Leichte Ketten
kappa
Konjugat
Unconjugated
Reinigung
Protein A affinity chromatography.
Konzentration
Reconstitution dependent.
Molekulargewicht
This antibody has a predicted MW of 145.84 kDa.
Reinheit
> 95% (by SDS-PAGE and SEC-HPLC).
Produktform
Lyophilized
Rekonstitution
Reconstitute with 100µl of sterile double-distilled water to bring antibody to 1mg/ml concentration. Gently shake to solubilize completely. Do not vortex!
Formulierung
Lyophilized from 25mM Histadine, pH 6.2, with 8% Sucrose and 0.01% Tween80.
Lagerung
Shipped at 4°C. Lyophilized: Store at -20°C to -80°C. Reconstituted: Aliquot and store at -80°C. Product is stable for one year. Avoid freeze/thaw cycles.
SDS-PAGE analysis of Anti-Claudin 6 Antibody [DS-9606a] - Low endotoxin, Azide free (A323967) under reducing (R) conditions confirms that the purity of this antibody is greater than 95%.
Human CLDN6 CHO cells were stained with Anti-Claudin 6 Antibody [DS-9606a] - Low endotoxin, Azide free (A323967) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC50 = 3.036 nM.
Anti-Claudin 6 Antibody [DS-9606a] - Low endotoxin, Azide free (A323967) by huCLDN6-HEK293 increased with the increase of antibody concentration, and the Internalization Rate (%) reached 60% at antibody concentration of 1 nM.
Anti-Claudin 6 Antibody [DS-9606a] - Low endotoxin, Azide free (A323967) inhibited the tumor growth of PA-1 on Balb/c nude mice. The result showed significant anti-tumor effects, with an tumor inhibition rate (TGI) of 84.7% at 5 mpk at D46.
![SDS-PAGE - Anti-Claudin 6 Antibody [DS-9606a] - Low endotoxin, Azide free (A323967) - Antibodies.com](https://cdn.antibodies.com/image/catalog/323/A323967_1.jpg?profile=product_top)
![SEC-HPLC - Anti-Claudin 6 Antibody [DS-9606a] - Low endotoxin, Azide free (A323967) - Antibodies.com](https://cdn.antibodies.com/image/catalog/323/A323967_2.jpg?profile=product_top)
![ELISA - Anti-Claudin 6 Antibody [DS-9606a] - Low endotoxin, Azide free (A323967) - Antibodies.com](https://cdn.antibodies.com/image/catalog/323/A323967_3.jpg?profile=product_top)
![FACS - Anti-Claudin 6 Antibody [DS-9606a] - Low endotoxin, Azide free (A323967) - Antibodies.com](https://cdn.antibodies.com/image/catalog/323/A323967_4.jpg?profile=product_top)
![Function:Internalization - Anti-Claudin 6 Antibody [DS-9606a] - Low endotoxin, Azide free (A323967) - Antibodies.com](https://cdn.antibodies.com/image/catalog/323/A323967_5.jpg?profile=product_top)
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![SDS-PAGE - Anti-Claudin 6 Antibody [DS-9606a] - Low endotoxin, Azide free (A323967) - Antibodies.com](https://cdn.antibodies.com/image/catalog/323/A323967_1.jpg?profile=product_top_thumb)
![SEC-HPLC - Anti-Claudin 6 Antibody [DS-9606a] - Low endotoxin, Azide free (A323967) - Antibodies.com](https://cdn.antibodies.com/image/catalog/323/A323967_2.jpg?profile=product_top_thumb)
![ELISA - Anti-Claudin 6 Antibody [DS-9606a] - Low endotoxin, Azide free (A323967) - Antibodies.com](https://cdn.antibodies.com/image/catalog/323/A323967_3.jpg?profile=product_top_thumb)
![FACS - Anti-Claudin 6 Antibody [DS-9606a] - Low endotoxin, Azide free (A323967) - Antibodies.com](https://cdn.antibodies.com/image/catalog/323/A323967_4.jpg?profile=product_top_thumb)
![Function:Internalization - Anti-Claudin 6 Antibody [DS-9606a] - Low endotoxin, Azide free (A323967) - Antibodies.com](https://cdn.antibodies.com/image/catalog/323/A323967_5.jpg?profile=product_top_thumb)
![Research in vivo - Anti-Claudin 6 Antibody [DS-9606a] - Low endotoxin, Azide free (A323967) - Antibodies.com](https://cdn.antibodies.com/image/catalog/323/A323967_6.jpg?profile=product_top_thumb)
![SDS-PAGE - Anti-Claudin 6 Antibody [DS-9606a] - Low endotoxin, Azide free (A323967) - Antibodies.com](https://cdn.antibodies.com/image/catalog/323/A323967_1.jpg?profile=product_image)
![SEC-HPLC - Anti-Claudin 6 Antibody [DS-9606a] - Low endotoxin, Azide free (A323967) - Antibodies.com](https://cdn.antibodies.com/image/catalog/323/A323967_2.jpg?profile=product_image)
![ELISA - Anti-Claudin 6 Antibody [DS-9606a] - Low endotoxin, Azide free (A323967) - Antibodies.com](https://cdn.antibodies.com/image/catalog/323/A323967_3.jpg?profile=product_image)
![FACS - Anti-Claudin 6 Antibody [DS-9606a] - Low endotoxin, Azide free (A323967) - Antibodies.com](https://cdn.antibodies.com/image/catalog/323/A323967_4.jpg?profile=product_image)
![Function:Internalization - Anti-Claudin 6 Antibody [DS-9606a] - Low endotoxin, Azide free (A323967) - Antibodies.com](https://cdn.antibodies.com/image/catalog/323/A323967_5.jpg?profile=product_image)
![Research in vivo - Anti-Claudin 6 Antibody [DS-9606a] - Low endotoxin, Azide free (A323967) - Antibodies.com](https://cdn.antibodies.com/image/catalog/323/A323967_6.jpg?profile=product_image)
![SDS-PAGE - Anti-Claudin 6 Antibody [IMAB027] - Low endotoxin, Azide free (A323968) - Antibodies.com](https://cdn.antibodies.com/image/catalog/323/A323968_1.jpg?profile=product_alternative)
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![SDS-PAGE - Anti-Claudin 6 Antibody [IM-302] - Low endotoxin, Azide free (A323974) - Antibodies.com](https://cdn.antibodies.com/image/catalog/323/A323974_1.jpg?profile=product_alternative)
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