Anti-CD62P Antikörper [A01-2H1] (A279579)

Anti-CD62P Antibody [A01-2H1]

Mouse monoclonal [A01-2H1] antibody to CD62P.

This antibody recognises CD63P, also known as P-Selectin, granule membrane protein 140, LECAM and PADGEM. CD62P is a member of the Selectin family of proteins which are transmembrane Ca2+-dependent lectins that mediate adhesion of leukocytes, platelets and the endothelium during inflammation and immune surveillance (McEver 2015). CD62P is expressed by megakaryocytes and endothelial cells and is stored in membranes of a-granules of platelets and Weibel-Palade bodies of endothelial cells. In humans CD62P can also be secreted as a molecule lacking the transmembrane domain. Increased levels of soluble CD62P in peripheral blood has been documented in a variety of diseases including heart disease, diabetes, hypertension and atrial fibrillation. The purified Mouse anti Human CD62P antibody, clone A01-2H1 (MCA62674GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human CD62P antibody, clone A05-6A1 (MCA6275B) as the detection antibody.

ELISA

ELISA: 1 µg/ml

Human

HEK293 derived recombinant human full length CD62P (Met1- Ala771).

Mouse

Monoclonal

A01-2H1

IgG1

Unconjugated

Protein G affinity chromatography of tissue culture supernatant.

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human CD62P antibody, clone A01-2H1, recognizes CD63P, also known as P-Selectin, granule membrane protein 140, LECAM and PADGEM. CD62P is a member of the Selectin family of proteins which are transmembrane Ca2+-dependent lectins that mediate adhesion of leukocytes, platelets and the endothelium during inflammation and immune surveillance (McEver 2015). CD62P is expressed by megakaryocytes and endothelial cells and is stored in membranes of a-granules of platelets and Weibel-Palade bodies of endothelial cells. In humans CD62P can also be secreted as a molecule lacking the transmembrane domain. Increased levels of soluble CD62P in peripheral blood has been documented in a variety of diseases including heart disease, diabetes, hypertension and atrial fibrillation (Polgar et al. 2005).The purified Mouse anti Human CD62P antibody, clone A01-2H1 (MCA62674GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human CD62P antibody, clone A05-6A1 (MCA6275B) as the detection antibody.

Antigen CD62, CD62, CD62 antigen like family member P, CD62 antigen-like family member P, FLJ45155, GMP 140, GMP-140, GMP140, GMRP, Granule membrane protein 140, Granule membrane protein 140kDa, Granulocyte membrane protein, GRMP, LECAM 3, LECAM3, Leukocyte endothelial cell adhesion molecule 3 , Leukocyte-endothelial cell adhesion molecule 3, LYAM3_HUMAN, P selectin, P-selectin, PADGEM, Platelet activation dependent granule external membrane protein, Platelet activation dependent granule-external membrane protein, Platelet alpha granule membrane protein, PSEL, Selectin P, Selectin P (granule membrane protein 140kDa antigen CD62), Selectin P (granule membrane protein 140kDa, antigen CD62), SELP