Anti-CD59 Antibody [YTH53.1] (A282088)

Anti-CD59 Antibody [YTH53.1]

Rat monoclonal [YTH53.1] antibody to CD59.

This antibody recognises the human CD59 cell surface antigen, also known as MAC-inhibitory protein, 1F5 antigen, 20 kDa homologous restriction factor, MEM43 antigen, membrane attack complex inhibition factor, membrane inhibitor of reactive lysis or protectin. CD59 is produced as a 103 amino acid proprotein, further processed to produce an 18-20 kDa GPI linked glycoprotein broadly expressed by human leucocytes and erythrocytes.Mutation of the CD59 gene can result in the presentation of Hemolytic anemia, CD59-mediated, with or without polyneuropathy (HACD59) a disease characterized by infantile onset of a relapsing-remitting polyneuropathy manifest as limb muscle weakness, and hyporeflexia.Rat anti Human CD59 antibody, clone YTH53.1 blocks the normal function of CD59.

WB, IHC-P, Flow Cytometry, IHC-Fr, Functional Assays, IF

Flow Cytometry: 1:50 - 1:100, IHC-P 2: 1:5 - 1:10, Use 10µl of the suggested working dilution to label 10⁶ cells in 100µl.

Human

Human Peripheral Blood T cells.

Rat

Monoclonal

YTH53.1

IgG2b

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rat anti Human CD59 antibody, clone YTH53.1 recognizes the human CD59 cell surface antigen, also known as MAC-inhibitory protein, 1F5 antigen, 20 kDa homologous restriction factor, MEM43 antigen, membrane attack complex inhibition factor, membrane inhibitor of reactive lysis or protectin. CD59 is produced as a 103 amino acid proprotein, further processed to produce an 18-20 kDa GPI linked glycoprotein broadly expressed by human leucocytes and erythrocytes.Mutation of the CD59 gene can result in the presentation of Hemolytic anemia, CD59-mediated, with or without polyneuropathy (HACD59) a disease characterized by infantile onset of a relapsing-remitting polyneuropathy manifest as limb muscle weakness, and hyporeflexia.Rat anti Human CD59 antibody, clone YTH53.1 blocks the normal function of CD59 (Walsh et al. 1991).

1F5 antigen, 20 kDa homologous restriction factor, CD59 glycoprotein, HRF-20, HRF20, MAC-inhibitory protein, MAC-IP, MACIF, MEM43 antigen, Membrane attack complex inhibition factor, MIC11, MIN1, MIN2, MIN3, MSK21