Anti-CD46 Antibody [MEM-258] (FITC) (A281136)

Anti-CD46 Antibody [MEM-258] (FITC)

Mouse monoclonal [MEM-258] antibody to CD46 (FITC).

This antibody recognises the human CD46 cell surface antigen, also known as membrane co-factor protein (MCP), Trophoblast leukocyte common antigen or TLX. CD46 is a 392 amino acid (including a 34 aa signal peptide) ~43-60 kDa single pass type 1 transmembrane glysoprotein expressed by all cell types with the exception of erythrocytes.CD46 functions as areceptor for complement and inhibitor of complement activation, limiting the formation and activity of C3 convertases. CD46 is expressed by all nucleated cells, often as multiple isoforms on the same cells. The molecule is also expressed by sperm and may be important in the process of fertilisation.

Flow Cytometry: Neat, Use 10µl of the suggested working dilution to label 10⁶ or 100µl whole blood.

Human

HPB-ALL cell line.

Mouse

Monoclonal

MEM-258

IgG1

Protein A affinity chromatography of tissue culture supernatant.

100 µg/ml

Liquid

Supplied in Phosphate Buffered Saline with 1% BSA and 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light.

Mouse anti Human CD46 antibody, clone MEM-258 recognizes the human CD46 cell surface antigen, also known as membrane co-factor protein (MCP), Trophoblast leukocyte common antigen or TLX. CD46 is a 392 amino acid (including a 34 aa signal peptide) ~43-60 kDa single pass type 1 transmembrane glysoprotein expressed by all cell types with the exception of erythrocytes.CD46 functions as areceptor for complement and inhibitor of complement activation, limiting the formation and activity of C3 convertases. CD46 is expressed by all nucleated cells, often as multiple isoforms (Seya et al. 1993) on the same cells. The molecule is also expressed by sperm and may be important in the process of fertilisation (Carver-Ward et al. 1996).

MCP, Membrane cofactor protein, MIC10, TLX, Trophoblast leukocyte common antigen

This product is for research use only. It is not intended for diagnostic or therapeutic use.