Anti-CD40L Antikörper [CD40LG/4675] (A278444)

Name: Anti-CD40L Antibody [CD40LG/4675] - BSA and Azide free
Brand: Antibodies.com
SKU: A278444
Price: 525.0 USD
Availability: InStock

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$525

Monoklonal [CD40LG/4675] Maus Antikörper gegen CD40L für IHC-P.

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Alternative Formats and ConjugatesAlternative Formats

Unconjugated

Versand

Versandkosten

$40

Vorlaufzeit

Lieferung in 4-6 Werktagen

Kontakt

Telefon

+1 (314) 370-6046

orders@antibodies.com

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Stichworte:

Monospezifischer Antikörper Plasma Membrane Marker

Produktdetails

Produktname

Anti-CD40L Antibody [CD40LG/4675] - BSA and Azide free

Beschreibung

Mouse monoclonal [CD40LG/4675] antibody to CD40L.

Spezifität

CD40LG expression is mainly confined to the CD4-positive-T-cell subset. Its expression is induced shortly after T-cell activation and represents an early activation marker of T lymphocytes. CD40 is constitutively expressed mainly on B cells, macrophages, and dendritic cells. The CD40-CD40L pathway has been shown to play multiple functional roles in the healthy immune system. It enhances the antigen-specific T-cell response through the activation of dendritic cells and the induction of interleukin-12 production. For example, engagement of CD40 on endothelial cells by activated T cells expressing CD40L leads to upregulation of adhesion molecules such as ICAM-1, VCAM-1, and E-selectin. Activation of APC by CD40-CD40L interaction induces the production of inflammatory cytokines, chemokines, NO, and metalloproteinases. Interaction of CD4-positiveCD40LG-positiveT cells with CD40 on B cells leads to B-cell differentiation, proliferation, immunoglobulin (Ig) isotype switching, and formation of memory B cells.

Anwendungen

IHC-P

Verdünnungen

IHC-P: 1-2 µg/ml

Reaktivität

Human

Immunogen

Recombinant fragment, around amino acids 108-261, of human CD40L protein. The exact sequence is proprietary.

Wirt

Mouse

Klonalität

Monoclonal

Klon

CD40LG/4675

Isotyp

IgG1

Leichte Ketten

kappa

Konjugat

Unconjugated

Reinigung

Protein A/G chromatography.

Konzentration

1 mg/ml

Molekulargewicht

36 kDa

Produktform

Liquid

Formulierung

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Lagerung

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Allgemeine Hinweise

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-CD40L Antibody [CD40LG/4675] (A277856).

Synonyme

CD 40L, CD154, CD40 antigen ligand, CD40 ligand, CD40 ligand, soluble form, CD40-L, CD40LG, CD40L_HUMAN, gp39, hCD40L, HIGM1, IGM, IMD3, soluble form, T B cell activating molecule, T BAM, T cell antigen Gp39 , T-cell antigen Gp39, TNF related activation protein, TNF-related activation protein, TNFSF5, TrAP, Tumor necrosis factor (ligand) superfamily member 5, Tumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM syndrome), Tumor necrosis factor ligand superfamily member 5

Isotyp-Kontrollantikörper

Kompatible Sekundärantikörper

Haftungsausschluss

Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.

Produktbilder (4)

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Figure 1: Immunohistochemistry - Anti-CD40L Antibody [CD40LG/4675] - BSA and Azide free (A278444)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human kidney tissue using Anti-CD40L Antibody [CD40LG/4675].

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Figure 2: Immunohistochemistry - Anti-CD40L Antibody [CD40LG/4675] - BSA and Azide free (A278444)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human liver carcinoma in colon tissue using Anti-CD40L Antibody [CD40LG/4675].

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Figure 3: SDS-PAGE - Anti-CD40L Antibody [CD40LG/4675] - BSA and Azide free (A278444)

SDS-PAGE analysis of Anti-CD40L Antibody [CD40LG/4675] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.

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Figure 4: Anti-CD40L Antibody [CD40LG/4675] - BSA and Azide free (A278444)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-CD40L Antibody [CD40LG/4675]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.