Mouse monoclonal [CB28] antibody to CD28 (CF® 488).
Spezifität
This antibody recognizes a glycoprotein of 44-88kDa, which is identified as CD28. It is the critical T-cell co-stimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its co-stimulation role, CD28 functions in preventing T-cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. CD28 is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader.
Anwendungen
Flow Cytometry, IF
Verdünnungen
Flow Cytometry: 5 µl / million cells or 5 µl / 100 µl whole blood, IF: 1:50-1:100
Reaktivität
Human
Immunogen
Recombinant human CD28 protein.
Wirt
Mouse
Klonalität
Monoclonal
Klon
CB28
Isotyp
IgG1
Leichte Ketten
kappa
Konjugat
CF® 488
Excitation: 490nm, Emission: 515nm
Reinigung
Protein A/G chromatography.
Konzentration
100 µg/ml
Molekulargewicht
44 kDa (monomer) / 88 kDa (dimer)
Produktform
Liquid
Formulierung
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Lagerung
Store at 4-8°C. Antibody is stable for 24 months.
Synonyme
CD 28, CD28 antigen, CD28 molecule, CD28_HUMAN, MGC138290, T cell antigen CD28, T cell specific surface glycoprotein, T cell specific surface glycoprotein CD28, T-cell-specific surface glycoprotein CD28, TP44
Haftungsausschluss
Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.
SDS-PAGE analysis of Anti-CD28 Antibody [CB28] (CF® 488) under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.