This antibody recognises human CD19 also known as T-cell surface antigen Leu-12 or B-lymphocyte surface antigen B4. CD19 is a ~95 kDa type I single pass transmembrane glycoprotein expressed on follicular dendritic cells and B-cells during maturation but is lost on development into plasma cells. CD19 is the broadest lineage specific marker for B cells and functions as a B-cell co-receptor in conjunction with CD21 , CD9, CD81 and CD82 (Horváth et al. 1998). CD19 is implicated in the down-regulation of B cell growth and proliferation.

Anwendungen

Flow Cytometry

Verdünnungen

Flow Cytometry: Neat, Use 10µl of the suggested working dilution to label 10⁶ cells in 100µl

Reaktivität

Human

Wirt

Mouse

Klonalität

Monoclonal

Klon

LT19

Isotyp

IgG1

Konjugat

Biotin

Reinigung

Protein A affinity chromatography of tissue culture supernatant.

Konzentration

100 µg/ml

Produktform

Liquid

Formulierung

Supplied in Phosphate Buffered Saline with 1% BSA and 0.09% Sodium Azide.

Lagerung

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light.

Allgemeine Hinweise

Mouse anti Human CD19 antibody, clone LT19 recognizes human CD19 also known as T-cell surface antigen Leu-12 or B-lymphocyte surface antigen B4. CD19 is a ~95 kDa type I single pass transmembrane glycoprotein expressed on follicular dendritic cells and B-cells during maturation but is lost on development into plasma cells (de Rie et al. 1989). CD19 is the broadest lineage specific marker for B cells and functions as a B-cell co-receptor in conjunction with CD21 (Bradbury et al. 1992), CD9, CD81 and CD82 (Horváth et al. 1998). CD19 is implicated in the down-regulation of B cell growth and proliferation (Pezzutto et al. 1987).

Synonyme

Antibody deficiency due to defect in CD19, included, AW495831, B lymphocyte antigen CD19, B lymphocyte surface antigen B4, B-lymphocyte antigen CD19, B-lymphocyte surface antigen B4, B4, CD19 antigen, CD19 molecule, Cd19 protein, CD19_HUMAN, CVID3, Differentiation antigen CD19, Leu 12, Leu-12, Leu12, MGC109570, MGC12802, T-cell surface antigen Leu-12

Isotyp-Kontrollantikörper