Anti-CCR9 Antikörper [9B1] (A279563)

Anti-CCR9 Antibody [9B1]

Rat monoclonal [9B1] antibody to CCR9.

This antibody recognises mouse chemokine receptor 9 (CCR9), also known as CD199. CCR9 is a seven transmembrane protein which is a member of the beta chemokines receptor family. CCR9 is expressed in thymus and small intestine, and mediates the recruitment and development of thymocytes in response to CCL25; the only known ligand of CCR9. CCR9 is an alternative co-receptor with CD4 for HIV infection, and has been implicated in adult T cell leukaemia. Two alternatively spliced transcript variants have been described.Clone 9B1 blocks CCL25-induced Ca2+ release, attenuating inflammation in a murine model of chronic ileitis when given in early disease stages.

Flow Cytometry

Flow Cytometry: 1:25 - 1:200, Use 10µl of the suggested working dilution to label 1x10⁶ cells in 100µl.

Mouse

A peptide corresponding to 25 amino acids from the N-terminus of murine CCR9, conjugated to Keyhole Limpet Haemocyanin.

Rat

Monoclonal

9B1

IgG2a

Unconjugated

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rat anti Mouse CD199 antibody, clone 9B1 detects mouse chemokine receptor 9 (CCR9), also known as CD199. CCR9 is a seven transmembrane protein which is a member of the beta chemokines receptor family. CCR9 is expressed in thymus and small intestine, and mediates the recruitment and development of thymocytes in response to CCL25; the only known ligand of CCR9. CCR9 is an alternative co-receptor with CD4 for HIV infection, and has been implicated in adult T cell leukaemia. Two alternatively spliced transcript variants have been described.Clone 9B1 blocks CCL25-induced Ca2+ release, attenuating inflammation in a murine model of chronic ileitis when given in early disease stages.

C C chemokine receptor D6, C C chemokine receptor type 9, C C CKR 9, CC Chemokine receptor CCR10, CC CKR 9, CCBP2, CCCKR9, CCR 9, CDw199, CDw199 antigen, Chemokine (C C motif) receptor 9, Chemokine (C C motif) receptor 9, isoform CRA_a, Chemokine (C-C motif) receptor 9 isoform A, Chemokine (C-C motif) receptor 9 isoform B, Chemokine C C motif receptor 9, Chemokine C C receptor 10, Chemokine CC Motif Receptor 9, Chemokine receptor CCR 9, Chemokine receptor CCR9, Chemokine-binding protein D6, Cmkbr10, CMKBR9, G protein coupled receptor 28, GPR 28, GPR 9 6, GPR28, GPR96, OTTHUMP00000164653, OTTHUMP00000164654