Anti-CCR3 Antibody (A282998)

Anti-CCR3 Antibody

Rabbit polyclonal antibody to CCR3.

This antibody recognises human CD193, otherwise known as CC chemokine receptor 3 (CCR3), a seven-helix transmembrane G-protein coupled receptor which, along with CCR5 and CXCR4, acts as a principal receptor for the fusion and entry of HIV into target cells. CD193 is expressed by eosinophils, basophils, mast cells, microglia, Th2 helper cells and some epithelial cells.CD193 acts as a receptor for several CC chemokines including monocyte chemoattractant proteins (MCP) -1, -2, -3 and -4, MIP-1a, MIP-1ß, and RANTES. The eotaxin subgroup of CC chemokines act as specific agonists for CD193 involved in infection of microglia by HIV and allergic reactions. Rabbit anti Human CD193 antibody has been used successfully for the detection of human CD193 by immunohistochemistry on formalin fixed, paraffin embedded intervertebral disc tissue.

WB, IHC-P, IF, IHC-Fr

IHC-P 1: 10 µg/ml, WB: 1 µg/ml

Human, Rat, Mouse

Synthetic peptide corresponding to 14 amino acids near human CD193 carboxy-terminus.

Rabbit

Polyclonal

IgG

Approximately 55 kDa in human spleen cell lysates (predicted Mwt. 41 kDa)

Liquid

Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti Human CD193 antibody recognizes human CD193, otherwise known as CC chemokine receptor 3 (CCR3), a seven-helix transmembrane G-protein coupled receptor which, along with CCR5 and CXCR4, acts as a principal receptor for the fusion and entry of HIV into target cells. CD193 is expressed by eosinophils, basophils, mast cells, microglia, Th2 helper cells and some epithelial cells.CD193 acts as a receptor for several CC chemokines including monocyte chemoattractant proteins (MCP) -1, -2, -3 and -4, MIP-1a, MIP-1ß, and RANTES. The eotaxin subgroup of CC chemokines act as specific agonists for CD193 involved in infection of microglia by HIV (He et al. 1997) and allergic reactions (Holse et al. 2006).Rabbit anti Human CD193 antibody has been used successfully for the detection of human CD193 by immunohistochemistry on formalin fixed, paraffin embedded intervertebral disc tissue (Gruber et al. 2014).

C C CKR3, C-C chemokine receptor type 3, CD193, CMKBR3, Eosinophil eotaxin receptor