This antibody recognises the Casitas B-lineage lymphoma (CBL) E3 ubiquitin ligase, also known as c-CBL proto-oncogene and ring finger protein 55. As the name implies, the viral form of CBL, v-CBL, has been shown to induce lymphoma and leukemia in mice. The CBL protein is a RING finger E3-ubiquitin ligase that plays a key role in signal transduction processes through mediating monoubiquitination and thereby endocytosis of receptor tyrosine kinases (Haglund et al. 2002, Dikic and Giordano 2003). In addition to this role, CBL has also been reported to act as an adaptor protein as well as a mediator of cell signaling processes by changing the cellular localization of substrates.

Anwendungen

Verdünnungen

WB: 1:200

Reaktivität

Human, Mouse, Rat

Immunogen

A peptide corresponding to the C-terminus of human E3 ubiquitin-protein ligase CBL.

Wirt

Rabbit

Klonalität

Polyclonal

Isotyp

IgG

Konjugat

Unconjugated

Reinigung

Affinity chromatography.

Konzentration

200 µg/ml

Molekulargewicht

Approximately 117 kDa when run under reducing conditions

Produktform

Liquid

Formulierung

Supplied in Phosphate Buffered Saline with 0.2% Gelatin and 0.1% Sodium Azide.

Lagerung

Store undiluted at 4°C. Do not freeze! Should this product contain a precipitate we recommend microcentrifugation before use.

Allgemeine Hinweise

Rabbit anti E3 ubiquitin-protein ligase CBL antibody recognizes the Casitas B-lineage lymphoma (CBL) E3 ubiquitin ligase, also known as c-CBL proto-oncogene and ring finger protein 55. As the name implies, the viral form of CBL, v-CBL, has been shown to induce lymphoma and leukemia in mice (de Jong et al. 1995).The CBL protein is a RING finger E3-ubiquitin ligase that plays a key role in signal transduction processes through mediating monoubiquitination and thereby endocytosis of receptor tyrosine kinases (Haglund et al. 2002, Dikic and Giordano 2003). In addition to this role, CBL has also been reported to act as an adaptor protein as well as a mediator of cell signaling processes by changing the cellular localization of substrates (Liyasova et al. 2015).

Synonyme

4732447J05Rik, C CBL, Cas Br M (murine) ecotropic retroviral transforming sequence, Casitas B lineage lymphoma proto oncogene, Casitas B-lineage lymphoma proto-oncogene, CBL 2, CBL2, CBL_HUMAN, E3 ubiquitin protein ligase CBL, E3 ubiquitin-protein ligase CBL, Oncogene CBL2, Proto oncogene c CBL, Proto-oncogene c-CBL, RGD1561386, RING finger protein 55, RNF55, Signal transduction protein CBL

Isotyp-Kontrollantikörper

Kompatible Sekundärantikörper

Haftungsausschluss

Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.