This antibody recognises calretinin, a ~29 kDa calcium binding protein found mostly in the central nervous system and retina. It is a cytoplasmic protein involved in the regulation of calcium concentration, which is important in the regulation of a large variety of neuronal functions, including neurotransmitter release, ionic channel permeability, enzyme activity, and gene transcription. Mice deficient in calretinin show impairment in motor coordination.Calretinin is a sensitive and specific marker for mast cells.
Anwendungen
WB, IHC-Fr
Verdünnungen
IHC-Fr: 1:500, WB: 1:1,000
Reaktivität
Guinea Pig, Rat, Human, Mouse, Primate
Immunogen
Purified guinea pig calretinin.
Wirt
Sheep
Klonalität
Polyclonal
Isotyp
IgG
Konjugat
Unconjugated
Konzentration
Lot Specific
Molekulargewicht
Approximately 29 kDa in rat cerebellum.
Produktform
Liquid
Formulierung
Supplied in TRIS Buffered Saline.
Lagerung
Store undiluted at -20°C only. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.
Allgemeine Hinweise
Sheep anti calretinin antibody recognizes calretinin, a ~29 kDa calcium binding protein found mostly in the central nervous system and retina. It is a cytoplasmic protein involved in the regulation of calcium concentration, which is important in the regulation of a large variety of neuronal functions, including neurotransmitter release, ionic channel permeability, enzyme activity, and gene transcription. Mice deficient in calretinin show impairment in motor coordination.Calretinin is a sensitive and specific marker for mast cells.