Anti-Cadherin 16 Antibody [CDH16/1071] - BSA and Azide free
Beschreibung
Mouse monoclonal [CDH16/1071] antibody to Cadherin 16.
Spezifität
This antibody recognizes a protein of 130kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels.Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.
Flow cytometric analysis of human HEK293 cells using Anti-Cadherin 16 Antibody [CDH16/1071] followed by Goat Anti-Mouse IgG (CF® 488) (Blue). Isotype Control (Red).
SDS-PAGE analysis of Anti-Cadherin 16 Antibody [CDH16/1071] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.
Immunohistochemical anaylsis of formalin-fixed, paraffin-embedded human kidney using Anti-Cadherin 16 Antibody [CDH16/1071] followed by goat anti-mouse IgG (CF® 640R) (Purple).