+1 (314) 370-6046 oderKontakt

Anti-C3 Antikörper [AB01-3B4] (A279621)

$340

Monoklonal [AB01-3B4] Maus Antikörper gegen C3 für WB.

Versandkosten
Vorlaufzeit
Lieferung in 4-6 Werktagen
Telefon
+1 (314) 370-6046
Mo bis Frei, 8am - 4pm AST
Email
orders@antibodies.com
Produktname
Anti-C3 Antibody [AB01-3B4]
Beschreibung
Mouse monoclonal [AB01-3B4] antibody to C3.
Spezifität
This antibody recognises complement C3. C3 is a central component of the classical, alternate and lectin pathways in the complement cascade which forms part of the innate immune defenses. The central position of C3 in the cascade has led to the emergence of immune invasion strategies by many human pathogens, including Staphylococcus aureus which expresses 2 proteins that interfere with the activation of C3. C3 Deficiencies in humans also show an increased susceptibility to bacterial infections in early childhood the development of autoimmune disease and kidney diseases. Conversely, complement over-activation can result in various disease pathologies, including induction of inflammatory pathways causing tissue damage. With complements’ role in various diseases, pharmaceutical and biotech companies have targeted the cascade for potential therapeutic targets in a range of immune and inflammatory diseases as well as in transplantation medicine. C3 is activated via its’ cleavage into fragments which have varying functions within the complement cascade.
Anwendungen
WB
Verdünnungen
WB: 1:1,000, Under reducing conditions the C3 alpha chain at an approximate molecular weight of 115 kDa and the C3c alpha chain fragment 2 at approximately 39 kDa can be detected by WB. Under non reducing conditions the mature C3 band can be detected at a molecular weight of approximately 186 kDa
Reaktivität
Human
Immunogen
E. coli derived recombinant human C3 (Gly1200-Asn1663).
Sequenz
GRLKGPLLNKFLTTAKDKNRWEDPGKQLYNVEATSYALLALLQLKDFDFVPPVVRWLNEQRYYGGGYGSTQATFMVFQALAQYQKDAPDHQELNLDVSLQLPSRSSKITHRIHWESASLLRSEETKENEGFTVTAEGKGQGTLSVVTMYHAKAKDQLTCNKFDLKVTIKPAPETEKRPQDAKNTMILEICTRYRGDQDATMSILDISMMTGFAPDTDDLKQLANGVDRYISKYELDKAFSDRNTLIIYLDKVSHSEDDCLAFKVHQYFNVELIQPGAVKVYAYYNLEESCTRFYHPEKEDGKLNKLCRDELCRCAEENCFIQKSDDKVTLEERLDKACEPGVDYVYKTRLVKVQLSNDFDEYIMAIEQTIKSGSDEVQVGQQRTFISPIKCREALKLEEKKHYLMWGLSSDFWGEKPNLSYIIGKDTWVEHWPEEDECQDEENQKQCQDLGAFTESMVVFGCPN
Wirt
Mouse
Klonalität
Monoclonal
Klon
AB01-3B4
Isotyp
IgG1
Konjugat

Unconjugated

Reinigung
Protein G affinity chromatography.
Konzentration
1 mg/ml
Molekulargewicht
Approximately 115 kDa and 39 kDa corresponding to the C3 alpha chain and the C3c alpha chain fragment 2 under reducing conditions. Under non-reducing conditions the mature C3 band can be detected at approximately 186 kDa.
Produktform
Liquid
Formulierung
Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.
Lagerung
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
Allgemeine Hinweise
Mouse anti Human C3 antibody, clone AB01-384 recognizes complement C3. C3 is a central component of the classical, alternate and lectin pathways in the complement cascade which forms part of the innate immune defenses. The central position of C3 in the cascade has led to the emergence of immune invasion strategies by many human pathogens, including Staphylococcus aureus which expresses 2 proteins that interfere with the activation of C3 (Garcia et al. 2012). C3 Deficiencies in humans also show an increased susceptibility to bacterial infections in early childhood the development of autoimmune disease and kidney diseases (Ricklin et al. 2016). Conversely, complement over-activation can result in various disease pathologies, including induction of inflammatory pathways causing tissue damage. With complements’ role in various diseases, pharmaceutical and biotech companies have targeted the cascade for potential therapeutic targets in a range of immune and inflammatory diseases as well as in transplantation medicine (Ricklin et al. 2012). C3 is activated via its’ cleavage into fragments which have varying functions within the complement cascade.
Synonyme
Acylation stimulating protein cleavage product , AHUS5, ARMD9, ASP, C3 and PZP like alpha 2 macroglobulin domain containing protein 1, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, C3a, C3a anaphylatoxin, C3adesArg, C3b, CO3_HUMAN, Complement C3, Complement C3c alpha'' chain fragment 2, Complement component 3, Complement component C3, Complement component C3a, Complement component C3b, Complement factor 3, CPAMD1, HEL S 62p, HSE-MSF, Prepro C3
Haftungsausschluss
Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.

Alternative Produkte zum Anti-C3 Antikörper [AB01-3B4] (A279621)

Oben