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Anti-BRCA1 (phospho Ser1423) Antikörper (A283562)

$420

Polyklonal Kaninchen Antikörper gegen BRCA1 (phospho Ser1423) für WB.

Versandkosten
Vorlaufzeit
Lieferung in 4-6 Werktagen
Telefon
+1 (314) 370-6046
Mo bis Frei, 8am - 4pm AST
Email
orders@antibodies.com
Produktname
Anti-BRCA1 (phospho Ser1423) Antibody
Beschreibung
Rabbit polyclonal antibody to BRCA1 (phospho Ser1423).
Spezifität
This antibody recognises breast cancer type 1 susceptibility protein encoded by BRCA1, also known as RING finger protein 53, when phosphorylated at serine 1423. Breast cancer susceptibility genes BRCA1 and BRCA2 are associated with hereditary breast and ovarian cancers. BRCA1 is a tumor suppressor gene encoding an E3 ubiquitin protein ligase that plays a major role in DNA damage repair. BRCA1 is also involved in the regulation of multiple processes including transcription and cell cycle progression. BRCA1 is reported to be phosphorylated by ATM and ATR at serine 1423 in response to DNA damage.
Anwendungen
WB
Verdünnungen
WB: 1:500 - 1:2,000
Reaktivität
Human
Immunogen
Phospho-specific peptide corresponding to residues surrounding Ser1423 of human BRCA1.
Wirt
Rabbit
Klonalität
Polyclonal
Isotyp
IgG
Konjugat

Unconjugated

Konzentration
Lot Specific
Produktform
Liquid
Formulierung
Supplied in Phosphate Buffered Saline with 50% Glycerol and 0.02% Sodium Azide.
Lagerung
Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.
Allgemeine Hinweise
Rabbit anti BRCA1 (pSer1423) antibody recognizes breast cancer type 1 susceptibility protein encoded by BRCA1, also known as RING finger protein 53, when phosphorylated at serine 1423. Breast cancer susceptibility genes BRCA1 and BRCA2 are associated with hereditary breast and ovarian cancers. BRCA1 is a tumor suppressor gene encoding an E3 ubiquitin protein ligase that plays a major role in DNA damage repair (Roy et al. 2011).BRCA1 is also involved in the regulation of multiple processes including transcription and cell cycle progression. BRCA1 is reported to be phosphorylated by ATM and ATR at serine 1423 in response to DNA damage (Tibbetts et al. 2000).
Synonyme
BRCA 1, BRCA1 DNA repair associated, BRCA1/BRCA2 containing complex subunit 1, BRCA1/BRCA2-containing complex, subunit 1, BRCA1_HUMAN, BRCAI, BRCC 1, BRCC1, Breast and ovarian cancer susceptibility protein 1, Breast Cancer 1, Breast Cancer 1 Early Onset, Breast cancer type 1 susceptibility protein, BROVCA1, FANCS, IRIS, PNCA4, PPP1R53, Protein phosphatase 1 regulatory subunit 53, PSCP, RING finger protein 53, RNF53
Isotyp-Kontrollantikörper
Haftungsausschluss
Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.

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