Anti-BCOR Antikörper [BCOR/2372] (A314502)

Anti-BCOR Antibody [BCOR/2372]

Mouse monoclonal [BCOR/2372] antibody to BCOR.

Bcl-6, a transcriptional repressor, can promote or inhibit apoptosis depending on the cell type and also plays an important role in normal immune responses. Bcl-6 negatively regulates NFB-mediated cellular functions and is frequently found to be deregulated in non-Hodgkin s lymphoma. BCoR (Bcl-6 corepressor) is a 1,755 amino acid protein that associates with histone deacetylases (HDACs) to transcriptionally repress Bcl-6. With ubiquitous expression, BCoR is localized to the nucleus where it interacts with other proteins through its three ANK repeat domains. Mutations in the gene encoding BCoR result in microphthalmia with associated anomalies 2, also known as anophthalmia, which is characterized by variable features, such as renal aplasia, mental retardation, hyospadias, microencephaly and cryptorchidism. There are four isoforms of BCoR which are produced as a result of alternative splicing events.

IHC-P

Ubiquitously expression.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 100-400) of human BCOR protein. The exact sequence is proprietary.

Mouse

Monoclonal

BCOR/2372

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

192 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

5830466J11Rik, 8430401K06Rik, ANOP 2, ANOP2, BCL 6 co repressor, BCL 6 corepressor, BCL 6 interacting corepressor, BCL-6 corepressor, BCL6 co repressor, BCL6 corepressor, BCL6 interacting corepressor, BCOR_HUMAN, FLJ20285, FLJ38041, KIAA1575, MAA 2, MAA2, MCOPS 2, MCOPS2, MGC131961, MGC71031