Anti-BCL11A Antibody [PCRP-BCL11A-1H3] - BSA and Azide free
Description
Mouse monoclonal [PCRP-BCL11A-1H3] antibody to BCL11A.
Specificity
Bcl-11a (CtIP-1, EVI9, B cell chronic lymphocytic leukemia (CLL)/lymphoma 11A) and Bcl-11b (CtIP-2, RIT1, B cell CLL/lymphoma 11B) genes play crucial roles in lymphopoiesis and influence the progression of hematopoietic malignancies. Disruption of the Bcl-11b locus is linked to T cell acute lymphoblastic leukemia, and the loss of heterozygosity in mice results in T cell lymphoma. Bcl-11 proteins are related C2H2 zinc-finger transcription factors that act as transcriptional repressors. Bcl-11b can interact with the metastasis-associated proteins MTA1 and MTA2 through the amino-terminal region. Bcl-11a is essential for postnatal development and normal lymphopoiesis. The Bcl-11a mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with Bcl-6.
SDS-PAGE analysis of Anti-BCL11A Antibody [PCRP-BCL11A-1H3] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.
Flow cytometric analysis of PFA-fixed HeLa cells using Anti-BCL11A Antibody [PCRP-BCL11A-1H3] followed by Goat Anti-Mouse IgG (CF® 488) (Blue). Isotype Control (Red).
Flow cytometric analysis of PFA-fixed Raji cells using Anti-BCL11A Antibody [PCRP-BCL11A-1H3] followed by Goat Anti-Mouse IgG (CF® 488) (Blue). Isotype Control (Red).
Anti-BCL11A Antibody [PCRP-BCL11A-1H3] - BSA and Azide free (A278339)
Analysis of protein array containing more than 19,000 full-length human proteins using Anti-BCL11A Antibody [PCRP-BCL11A-1H3]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
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