Anti-DBC-1 Antibody [PCRP-KIAA1967-1D10] (A314878)

Anti-DBC-1 Antibody [PCRP-KIAA1967-1D10]

Mouse monoclonal [PCRP-KIAA1967-1D10] antibody to DBC-1.

DBC-1 (deleted in breast cancer gene 1 protein), also known as p30 DBC protein, is one of the genes located within the region of chromosome 8p21.3 that is homozygously deleted in some breast cancers. DBC-1 contains a nuclear localization signal, an N-terminal leucine zipper, an EF hand and a C-terminal coiled-coil region. DBC-1 is closely related to DIS but lacks the SAP domain. During death signaling mediated by TNF, stabilizing its expression and therefore collaborating to suppress apoptosis and promote hormone-independent cell growth.

Flow Cytometry, IHC-P

Expressed ubiquitously in normal tissues. Expressed in 84 to 100% of neoplastic breast, lung, and colon tissues.

Flow Cytometry: 1-2 µg/million cells, IHC: 1-2 µg/ml

Human

Recombinant full-length human CCAR2 / KIAA1967 protein.

Mouse

Monoclonal

PCRP-KIAA1967-1D10

IgG2a

Protein A/G chromatography.

200 µg/ml

102.9 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

CCAR2, Cell cycle and apoptosis regulator 2, Cell division cycle and apoptosis regulator protein 2, DBC.1, DBC1, DBIRD complex subunit KIAA1967, Deleted in breast cancer 1, Deleted in breast cancer gene 1 protein, K1967_HUMAN, KIAA1967, NET35, p30 DBC, p30 DBC protein, p30DBC