Anti-Cytokeratin 6 Antibody [SPM269] (A249128)

Anti-Cytokeratin 6 Antibody [SPM269]

Mouse monoclonal [SPM269] antibody to Cytokeratin 6.

This antibody recognizes a protein of 56kDa, identified as cytokeratin 6 (CK6). In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and Cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human Cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies. Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Keratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation.

Flow Cytometry, IF, IHC-P

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Human, Mouse

Synthetic peptide corresponding to the C terminus of human Keratin 6.

GSSTIKYTTTS

Mouse

Monoclonal

SPM269

IgG2a

kappa

Protein A/G chromatography.

200 µg/ml

56 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Cytokeratin 6 Antibody [SPM269] - BSA and Azide free (A252308).

CK 6A, CK 6B, CK 6C, CK 6D, CK 6E, CK-6C, CK-6E, Cytokeratin 6a, Cytokeratin 6B, Cytokeratin 6C, Cytokeratin 6D, Cytokeratin 6E, Cytokeratin-6C, Cytokeratin-6E, K2C6C_HUMAN, K6a keratin, K6b keratin, K6C, K6c keratin, K6d keratin, K6e keratin, Keratin, Keratin K6h, Keratin type II cytoskeletal 6A, Keratin type II cytoskeletal 6B, Keratin type II cytoskeletal 6C, Keratin type II cytoskeletal 6D, Keratin type II cytoskeletal 6E, Keratin-6C, KRT6A, KRT6B, KRT6C, KRT6D, KRT6E, type II cytoskeletal 6C, Type-II keratin Kb12