Recombinant Anti-COX2 Antibody [COX2/7803R] (A314810)

$765

Recombinant rabbit monoclonal [COX2/7803R] antibody to COX2 for IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-COX2 Antibody [COX2/7803R]
Description
Recombinant rabbit monoclonal [COX2/7803R] antibody to COX2.
Specificity
Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA). Cox-1 and Cox-2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS). Cox-1 is constitutively expressed in most tissues and is thought to serve in general housekeeping functions. Cox-2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs, NSAIDs. COX2 expression is significantly increased in 85-90% of human colorectal adenocarcinomas whereas levels of COX-1 are not changed.
Applications
IHC-P
Positive Control
Human colon or lung carcinoma tissue (IHC).
Dilutions
IHC: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment (around Amino Acids 400-604) of human PTGS2 protein. The exact sequence is proprietary.
Host
Rabbit
Clonality
Monoclonal
Clone ID
COX2/7803R
Isotype
IgG
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
70-72 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
COX 2, COX-2, Cyclooxygenase 2, Cyclooxygenase 2b, Cyclooxygenase-2, Glucocorticoid-regulated inframmatory prostagandin G/H synthase, GRIPGHS, hCox 2, PGG/HS, PGH synthase 2, PGH2_HUMAN, PGHS 2, PGHS-2, PGHS2, PHS 2, PHS II, Prostaglandin endoperoxide synthase 2, Prostaglandin endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase), Prostaglandin G/H synthase 2, Prostaglandin G/H synthase and cyclooxygenase, Prostaglandin H2 synthase 2, Prostaglandin-endoperoxide synthase 2, PTGS2
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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