Recombinant chimeric monoclonal [IMAB027] antibody to Claudin 6.
Applications
ELISA, FACS, Functional Assay, In Vivo
Reactivity
Human
Host
Mouse / Human
Clonality
Monoclonal
Clone ID
IMAB027
Isotype
IgG1
Conjugate
Unconjugated
Purification
Protein A affinity chromatography.
Concentration
Reconstitution dependent.
Molecular Weight
This antibody has a predicted MW of 144.42 kDa.
Purity
> 95% (by SDS-PAGE and SEC-HPLC).
Product Form
Lyophilized
Reconstitution
Reconstitute with 100µl of sterile double-distilled water to bring antibody to 1mg/ml concentration. Gently shake to solubilize completely. Do not vortex!
Formulation
Lyophilized from 25mM Histadine, pH 6.2, with 8% Sucrose and 0.01% Tween80.
Storage
Shipped at 4°C. Lyophilized: Store at -20°C to -80°C. Reconstituted: Aliquot and store at -80°C. Product is stable for one year. Avoid freeze/thaw cycles.
SDS-PAGE analysis of Anti-Claudin 6 Antibody [IMAB027] - Low endotoxin, Azide free (A323968) under reducing (R) conditions confirms that the purity of this antibody is greater than 95%.
Human CLDN6 CHO cells were stained with Anti-Claudin 6 Antibody [IMAB027] - Low endotoxin, Azide free (A323968) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC50 = 4.342 nM.
Anti-Claudin 6 Antibody [IMAB027] - Low endotoxin, Azide free (A323968) induced ADCC activity was evaluated using Human CD16a (158V) (Luc) Jurkat Reporter Cell. The max induction fold was approximately 14.16.
Anti-Claudin 6 Antibody [IMAB027] - Low endotoxin, Azide free (A323968) by huCLDN6-HEK293 increased with the increase of antibody concentration, and the Internalization Rate (%) reached 60% at antibody concentration of 1 nM.
Anti-Claudin 6 Antibody [IMAB027] - Low endotoxin, Azide free (A323968) inhibited the tumor growth of OV90 on Balb/c nude mice. The result showed significant anti-tumor effects, with an tumor inhibition rate (TGI) of 50.7% at 5 mpk at D34.
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