Recombinant Anti-CFTR Antibody [CFTR/7003R] (A277960)

Anti-CFTR Antibody [CFTR/7003R]

Recombinant rabbit monoclonal [CFTR/7003R] antibody to CFTR.

This antibody recognizes a protein of 165-170kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 258-385, of human CFTR protein. The exact sequence is proprietary.

Rabbit

Monoclonal

CFTR/7003R

IgG

Unconjugated

200 µg/ml

165-170 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-CFTR Antibody [CFTR/7003R] - BSA and Azide free (A278548).

ABC 35, ABC35, ABCC 7, ABCC7, ATP binding cassette sub family C member 7, ATP Binding Cassette Superfamily C Member 7, ATP binding cassette transporter sub family C member 7, ATP-binding cassette sub-family C member 7, cAMP dependent chloride channel, cAMP-dependent chloride channel, CF, CFTR/MRP, CFTR_HUMAN, Channel conductance controlling ATPase, Channel conductance-controlling ATPase, Cystic fibrosis transmembrane conductance regulator, Cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub family C, member 7), Cystic fibrosis transmembrane conductance regulator ATP binding cassette sub family C member 7, Cystic Fibrosis Transmembrane Regulator, dJ760C5.1, MRP 7, MRP7, TNR CFTR