Anti-Ceruloplasmin Antibody (A282733)

Anti-Ceruloplasmin Antibody

Sheep polyclonal antibody to Ceruloplasmin.

This antibody recognises ceruloplasmin, a ~132kDa metalloprotein that is secreted into the plasma by liver hepatocytes and activated monocytes/macrophages. Ceruloplasmin functions in copper transport, iron homeostasis, antioxidant defence, angiogenesis and coagulation.Deficiency in ceruloplasmin is termed aceruloplasminemia, an autosomal recessive disorder which leads to iron accumulation and tissue damage, in particular in the brain and visceral organs. Clinical features include retinal degeneration, diabetes mellitus and neurological disturbances.Elevated plasma ceruloplasmin has been shown to pose an increased risk in atherosclerosis and myocardial infarction.

ELISA, IHC-Fr

This antibody has been used at dilutions as high as 1:400K in a simple ELISA with 0.1 µg of antigen coated per well.

Human

Highly purified human ceruloplasmin.

Sheep

Polyclonal

IgG

Affinity chromatography.

5 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Sheep anti Human ceruloplasmin antibody detects ceruloplasmin, a ~132kDa metalloprotein that is secreted into the plasma by liver hepatocytes and activated monocytes/macrophages. Ceruloplasmin functions in copper transport, iron homeostasis, antioxidant defence, angiogenesis and coagulation.Deficiency in ceruloplasmin is termed aceruloplasminemia, an autosomal recessive disorder which leads to iron accumulation and tissue damage, in particular in the brain and visceral organs. Clinical features include retinal degeneration, diabetes mellitus and neurological disturbances.Elevated plasma ceruloplasmin has been shown to pose an increased risk in atherosclerosis and myocardial infarction.

CERU_HUMAN, CP, CP 2, CP2, Ferroxidase