This antibody recognises an extracellular region of human B-cell antigen receptor complex-associated protein beta chain, also known as CD79b, B-cell-specific glycoprotein B29, Ig-beta or, Immunoglobulin-associated B29. CD79b is a cell surface antigen expressed by B lymphocytes and associates with CD79a to form a heterodimer, non-covalently linked to surface immunoglobulin, forming the B-cell receptor (BCR) complex.Mutations in the CD79B gene can lead to presentation of Agammaglobulinemia 6, autosomal recessive (AGM6), a disease demonstrating low or absent circulating B cells with the concomitant absence of antibody production. Patients present with multiple severe infections early in life.

Applications

Flow Cytometry

Dilutions

Flow Cytometry: Neat, Use 10µl of the suggested working dilution to label 10⁶ cells in 100µl

Reactivity

Human

Immunogen

A peptide corresponding to the extracellular region of CD79 beta.

Host

Mouse

Clonality

Monoclonal

Clone ID

AT105-1

Isotype

IgG1

Conjugate

FITC

Excitation: 490nm, Emission: 525nm

Purification

Protein A affinity chromatography of tissue culture supernatant.

Concentration

100 µg/ml

Product Form

Liquid

Formulation

Supplied in Phosphate Buffered Saline with 1% BSA and 0.09% Sodium Azide.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light.

General Notes

Mouse anti Human CD79b antibody, clone AT105-1 recognizes an extracellular region of human B-cell antigen receptor complex-associated protein beta chain, also known as CD79b, B-cell-specific glycoprotein B29, Ig-beta or, Immunoglobulin-associated B29. CD79b is a cell surface antigen expressed by B lymphocytes and associates with CD79a to form a heterodimer, non-covalently linked to surface immunoglobulin, forming the B-cell receptor (BCR) complex.Mutations in the CD79B gene can lead to presentation of Agammaglobulinemia 6, autosomal recessive (AGM6), a disease demonstrating low or absent circulating B cells with the concomitant absence of antibody production. Patients present with multiple severe infections early in life (Dobbs et al. 2007).

Synonyms

AGM6, B cell antigen receptor complex associated protein beta chain, B cell specific glycoprotein B29, B-cell antigen receptor complex-associated protein beta chain, B-cell-specific glycoprotein B29, B29, B29/Ig-beta/CD79b, CD 79b, CD79b antigen, CD79b antigen (immunoglobulin associated beta), CD79b molecule, CD79b molecule immunoglobulin associated beta, CD79b protein, CD79B_HUMAN, Ig beta, Ig-beta, IGB, Igbeta, Immunoglobulin associated B29, Immunoglobulin associated B29 protein, Immunoglobulin associated beta, Immunoglobulin associated protein, Immunoglobulin-associated B29 protein, MGC108607

Isotype Controls