Anti-CD46 Antibody [169-1-E4.3] - BSA and Azide free (A252489)

Anti-CD46 Antibody [169-1-E4.3] - BSA and Azide free

Mouse monoclonal [169-1-E4.3] antibody to CD46.

This antibody recognizes a protein of 52kDa-58kDa, identified as CD46 (also known as membrane cofactor protein, MCP). Its epitope is located on the four immunogenic short consensus repeat (SCR) domains at N-terminus of the protein. CD46 exists as many isoforms in a variety of tissues. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. CD46 functions as a C3b/C4b-binding glycoprotein that inhibits complement activation on host cells. It also serves as a measles virus receptor, an adherence factor for group Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria.

Flow Cytometry, IF

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml

Human, Baboon

This antibody does not react with Horse.

Stimulated human leukocytes.

Mouse

Monoclonal

169-1-E4.3

IgG2a

1 mg/ml

52-58 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-CD46 Antibody [169-1-E4.3] (A249309).

MCP, Membrane cofactor protein, MIC10, TLX, Trophoblast leukocyte common antigen