Anti-CD41 Antibody [PM6/248] (A281574)

Anti-CD41 Antibody [PM6/248]

Mouse monoclonal [PM6/248] antibody to CD41.

This antibody recognises the human CD41 cell surface antigen, a ~140 kDa glycoprotein expressed by platelets and megakaryocytes. CD41 is also known as platelet glycoprotein IIb, and functions as a receptor for fibrinogen, fibronectin and vWF.It has not been established if clone PM6/248 recognises free CD41 or CD41 only when complexed with CD61. However, antibody binding is reduced in the presence of EDTA suggesting that the epitope recognized is dependent upon an intact CD41/61 complex.

Use 10µl of the suggested working dilution to label 10⁶ cells or 100µl whole blood

Human, Baboon

Human platelet plasma membranes.

Mouse

Monoclonal

PM6/248

IgG1

Unconjugated

Protein A affinity chromatography of tissue culture supernatant.

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human CD41 antibody, clone PM6/248 recognizes the human CD41 cell surface antigen, a ~140 kDa glycoprotein expressed by platelets and megakaryocytes. CD41 is also known as platelet glycoprotein IIb, and functions as a receptor for fibrinogen, fibronectin and vWF.It has not been established if clone PM6/248 recognizes free CD41 or CD41 only when complexed with CD61. However, antibody binding is reduced in the presence of EDTA suggesting that the epitope recognized is dependent upon an intact CD41/61 complex.

antigen CD41, BDPLT16, BDPLT2, CD41B, form 2, GP2B, GPalpha IIb, GPIIb, GT, GTA, HPA3, Integrin alpha 2b, Integrin alpha IIb, Integrin alpha-IIb light chain, Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41), ITA2B_HUMAN, Itga2b, ITGAB, platelet fibrinogen receptor, alpha subunit, platelet glycoprotein IIb of IIb/IIIa complex, Platelet membrane glycoprotein IIb, platelet specific antigen BAK, PPP1R93