Anti-CD40 Antibody [CD40/4940] (A314704)

$765

Mouse monoclonal [CD40/4940] antibody to CD40 for ELISA and IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-CD40 Antibody [CD40/4940]
Description
Mouse monoclonal [CD40/4940] antibody to CD40.
Specificity
CD40 is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is expressed on B-lymphocytes, follicular dendritic cells, bone marrow-derived dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zones of secondary lymphoid organs.
Applications
ELISA, IHC-P
Positive Control
U2OS or L-428 cells. Human tonsil, spleen or thymus.
Dilutions
IHC: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment of human CD40 protein (around Amino Acids 1-200). The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
CD40/4940
Isotype
IgG1
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
43 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
AI326936, B cell associated molecule , B cell associated molecule CD40, B cell surface antigen CD40 , B cell-associated molecule, B-cell surface antigen CD40, Bp50, CD 40 , CD40 antigen , CD40 antigen (TNF receptor superfamily member 5), CD40 molecule , CD40 molecule TNF receptor superfamily member 5, CD40 molecule, TNF receptor superfamily member 5, CD40 protein , CD40 type II isoform , CD40L receptor , CDw40, GP39 , HIGM1, IGM , IMD3, MGC9013, Nerve growth factor receptor related B lymphocyte activation molecule , NFRSF5 , OTTHUMP00000031699, OTTHUMP00000031700 , p50, T BAM , T-BAM, TBAM, TNF receptor superfamily member 5, TNFRSF5, TNR5_HUMAN, TRAP, Tumor necrosis factor receptor superfamily , member 5, Tumor necrosis factor receptor superfamily member 5, Tumor necrosis factor receptor superfamily member 5 precursor , Tumor necrosis factor receptor superfamily, member 5, isoform CRA_a
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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