Anti-CD34 Antibody [ICO-115] (CF® 488) (A251164)

This product is discontinued

Anti-CD34 Antibody [ICO-115] (CF® 488) (A251164) has been discontinued and is no longer available.

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Name
Anti-CD34 Antibody [ICO-115] (CF® 488)
Description
Mouse monoclonal [ICO-115] antibody to CD34 (CF® 488).
Specificity
This antibody recognizes a carbohydrate epitope on a single chain, transmembrane, heavily glycosylated protein of 90-120kDa, which is identified as CD34 (VI international workshop on human differentiation antigens). Its expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, it is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. CD34 expression is also found in vascular endothelium. Additionally, it appears that proliferating endothelial cells overexpress this molecule than the non-proliferating endothelial cells. Anti-CD34 labels 85% of angiosarcoma and Kaposis sarcoma, but shows low specificity.
Applications
Flow Cytometry, IF
Dilutions
Flow Cytometry: 5 µl / million cells or 5 µl / 100 µl whole blood, IF: 1:50-1:100
Reactivity
Human, Rat
Immunogen
Blast cells of a chronic myeloid leukemia patient.
Host
Mouse
Clonality
Monoclonal
Clone ID
ICO-115
Isotype
IgG1
Light Chains
kappa
Conjugate

CF® 488

Excitation: 490nm, Emission: 515nm

Purification
Protein A/G chromatography.
Concentration
100 µg/ml
Molecular Weight
90-110 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Store at 4-8°C. Antibody is stable for 24 months.
Synonyms
CD34 antigen, CD34 molecule, CD34_HUMAN, Cluster designation 34, Hematopoietic progenitor cell antigen CD34, HPCA1, Mucosialin, OTTHUMP00000034733, OTTHUMP00000034734
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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