Recombinant Anti-CD33 Antibody [SIGLEC3/7046R] (A278099)

Anti-CD33 Antibody [SIGLEC3/7046R]

Recombinant rabbit monoclonal [SIGLEC3/7046R] antibody to CD33.

This antibody recognizes a 67kDa glycoprotein, which is identified as CD33. It is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 51-224, of human CD33 protein. The exact sequence is proprietary.

Rabbit

Monoclonal

SIGLEC3/7046R

IgG

kappa

Protein A/G chromatography.

200 µg/ml

67 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-CD33 Antibody [SIGLEC3/7046R] - BSA and Azide free (A278687).

CD 33, CD33 antigen, CD33 antigen (gp67), CD33 molecule, CD33_HUMAN, FLJ00391, gp67, My9, Myeloid cell surface antigen CD33, Myeloid cell surface antigen CD33 precursor, Myeloid differentiation antigen CD33, p67, Sialic acid binding Ig like lectin 3, Sialic acid binding immunoglobulin like lectin 3, Sialic acid-binding Ig-like lectin 3, SIGLEC 3, Siglec-3, SIGLEC3