Anti-CD32 Antibody [FCGR2A/479] - BSA and Azide free (A251714)

Anti-CD32 Antibody [FCGR2A/479] - BSA and Azide free

Mouse monoclonal [FCGR2A/479] antibody to CD32.

This antibody binds most strongly to the IIa isoforms of CD32 (FcRII), a type 1 transmembrane glycoprotein that mediates several functions including phagocytosis, cytotoxicity, and immunomodulation as well as platelet aggregation. Three genes (A, B, and C) encode CD32 and at least 6 isoforms are generated via alternative mRNA splicing, i.e., IIa1, IIa2, IIb1, IIb2, IIb3 and IIc. Monocytes/macrophages, placental trophoblasts and endothelial cells express all isoforms. In addition, the IIb isoform is expressed by B cells, and the IIa isoform by platelets, granulocytes and, weakly, by B cells. NK cells and neutrophils express Isoform IIc. CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune complexes.

Functional Studies, Flow Cytometry, IF

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml

Human

Recombinant human FCGR2A protein.

Mouse

Monoclonal

FCGR2A/479

IgG2b

kappa

Protein A/G chromatography.

1 mg/ml

40 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-CD32 Antibody [FCGR2A/479] (A248532).

8D6 antigen, 8D6A, CD320, CD320 antigen, CDw32, Fc-gamma RII-a, Fc-gamma RII-b, Fc-gamma RII-c, Fc-gamma-RIIa, Fc-gamma-RIIb, Fc-gamma-RIIc, FCG2, FCGR2A, FCGR2A1, FCGR2B, FCGR2C, FcRII-a, FcRII-b, FcRII-c, FDC-signaling molecule 8D6, FDC-SM-8D6, IGFR2, IgG Fc receptor II-a, IgG Fc receptor II-b, IgG Fc receptor II-c, Low affinity immunoglobulin gamma Fc region receptor II-a, Low affinity immunoglobulin gamma Fc region receptor II-b, Low affinity immunoglobulin gamma Fc region receptor II-c, TCblR, Transcobalamin receptor