Anti-CD276 Antibody [B7H3/4312] (A314642)

Anti-CD276 Antibody [B7H3/4312]

Mouse monoclonal [B7H3/4312] antibody to CD276.

T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory molecules. One such molecule, B7-H3 (B7-homolog 3, also designated B7RP-2) belongs to the B7 immunoglobulin superfamily. Soluble B7-H3 binds a putative receptor on activated T-cells that is distinct from CD28, CTLA-4, ICOS and PD-1. Widely expressed on nonlymphoid tissues, B7-H3 costimulates proliferation of both CD4+ and CD8+ T cells. The ability of B7-H3 to stimulate Th1 and cytotoxic-T cell responses suggest that it may have antitumor activity. B7-H3 interactions may play a role in regulating cell-mediated immune responses against cancer, implicating B7-H3 as a potential therapeutic tool.

Human tonsil, placenta, hepatocellular carcinoma or lung carcinoma.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 100-300) of human CD276 protein. The exact sequence is proprietary.

Mouse

Monoclonal

B7H3/4312

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

B7-H3 isoforms: 57 kDa / 34 kDa / 53 kDa / 57 kDa / glycosylated B7-H3: 90-110 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

4Ig B7 H3, 4Ig-B7-H3, AU016588, B7 H3, B7 homolog 3, B7-H3, B7H3, B7RP-2, CD276 antigen, CD276 molecule, CD276_HUMAN, CD_antigen=CD276, Costimulatory molecule, Flags: Precursor, PSEC0249, UNQ309/PRO352