Anti-CD1c Antibody [CD1C/1603] (A250479)

Anti-CD1c Antibody [CD1C/1603]

Mouse monoclonal [CD1C/1603] antibody to CD1c.

The CD1 multigene family encodes five forms of the CD1 T-cell surface glycoprotein in human, designated CD1A, 1B, 1C, 1D and 1E. CD1, a type 1 membrane protein, has structural similarity to the MHC class I antigen and has been shown to present lipid antigens for recognition by T lymphocytes. CD1 antigens are associated with -2-Microglobulin and expressed on cortical thymocytes, Langerhans cells, a B cell subset and some dendritic cells. Specifically, CD1A is a marker for Langerhans cell histiocytosis (LCH) and is found on interdigitating cells. Adaptor-protein complexes and CD1-associated chaperones control CD1 trafficking, and the development and activation of CD1-restricted T cells. Constitutive endocytosis of CD1B molecules and the differential sorting of MHC class II from lysosomes separate peptide- and lipid antigen-presenting molecules during dendritic cell maturation. CD1B is also expressed in interdigitating cells. The human CD1 genes are all closely linked in a cluster mapping at chromosome 1q23.1

Human

Recombinant full-length human CD1c protein.

Mouse

Monoclonal

CD1C/1603

IgG1

kappa

Protein A/G chromatography.

200 µg/ml

43 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-CD1c Antibody [CD1C/1603] - BSA and Azide free (A253659).

BDCA1, CD1, CD1A, CD1c antigen, CD1C antigen c polypeptide, CD1c molecule, CD1C_HUMAN, Cortical thymocyte antigen CD1C, Differentiation antigen CD1 alpha 3, R7, T cell surface glycoprotein CD1c, T-cell surface glycoprotein CD1c