Anti-CD19 Antibody [LT19] (A280950)

Anti-CD19 Antibody [LT19]

Mouse monoclonal [LT19] antibody to CD19.

This antibody recognises human CD19 also known as T-cell surface antigen Leu-12 or B-lymphocyte surface antigen B4. CD19 is a ~95 kDa type I single pass transmembrane glycoprotein expressed on follicular dendritic cells and B-cells during maturation but is lost on development into plasma cells. CD19 is the broadest lineage specific marker for B cells and functions as a B-cell co-receptor in conjunction with CD21 , CD9, CD81 and CD82 (Horváth et al. 1998). CD19 is implicated in the down-regulation of B cell growth and proliferation.

Flow Cytometry, IHC-Fr, IP

Flow Cytometry: 1:50 - 1:100, Use 10µl of the suggested working dilution to label 10⁶ cells in 100µl

Human

Mouse

Monoclonal

LT19

IgG1

Unconjugated

Protein A affinity chromatography of tissue culture supernatant.

Liquid

Supplied in Phosphate Buffered Saline.

Store undiluted at -20°C only. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Mouse anti Human CD19 antibody, clone LT19 recognizes human CD19 also known as T-cell surface antigen Leu-12 or B-lymphocyte surface antigen B4. CD19 is a ~95 kDa type I single pass transmembrane glycoprotein expressed on follicular dendritic cells and B-cells during maturation but is lost on development into plasma cells (de Rie et al. 1989). CD19 is the broadest lineage specific marker for B cells and functions as a B-cell co-receptor in conjunction with CD21 (Bradbury et al. 1992), CD9, CD81 and CD82 (Horváth et al. 1998). CD19 is implicated in the down-regulation of B cell growth and proliferation (Pezzutto et al. 1987).

Antibody deficiency due to defect in CD19, included, AW495831, B lymphocyte antigen CD19, B lymphocyte surface antigen B4, B-lymphocyte antigen CD19, B-lymphocyte surface antigen B4, B4, CD19 antigen, CD19 molecule, Cd19 protein, CD19_HUMAN, CVID3, Differentiation antigen CD19, Leu 12, Leu-12, Leu12, MGC109570, MGC12802, T-cell surface antigen Leu-12