Anti-CD11a Antibody [MEM-25] (A281135)

$375

Mouse monoclonal [MEM-25] antibody to CD11a for Flow Cytometry, IP and Functional Assays.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-CD11a Antibody [MEM-25]
Description
Mouse monoclonal [MEM-25] antibody to CD11a.
Specificity
This antibody recognises the integrin alphaL subunit, a 170-180 kDa type I transmembrane glycoprotein that associates with CD18 to form the leucocyte function-associated antigen-1, an alphaLbeta2 integrin expressed at the surface of all human leukocyte.LFA-1 is a receptor for ICAMs, JAM-1 and F11R. Its interaction with endothelial ligands, such as ICAM-1 and JAM-1 is responsible for leukocyte arrest and extravasation. In addition to its role in leukocyte adhesion and transmigration, LFA-1 is involved in T cell differentiation (Verma et al. 2016, Verman and Kelleher 2017) and is required for the effective lysis of infected cells by cytotoxic T cells (Anikeeva et al. 2005, Pontes Ferreira et al. 2017). LFA-1 also contributes to NK cell cytotoxicity and participates to the clearance of apoptotic neutrophils by macrophages (Kristóf et al. 2013). The interaction of LFA-1 with ICAM-1 is the target of Lifitegrast, a drug approved for the treatment of Dry Eye Disease. Mouse anti Human CD11 antibody, clone MEM-25 inhibits the cytotoxic activity of NK cells.
Applications
Flow Cytometry, IP, Functional Assays
Dilutions
Flow Cytometry: Neat - 1:50, Use 10µl of the suggested working dilution to label 1x106 cells in 100µl
Reactivity
Human
Immunogen
Leucocytes from a patient suffering from a LGL-type leukemia.
Host
Mouse
Clonality
Monoclonal
Clone ID
MEM-25
Isotype
IgG1
Conjugate

Unconjugated

Purification
Protein A affinity chromatography of tissue culture supernatant and 0.2µM filter sterilized.
Concentration
1 mg/ml
Purity
>95% (by SDS-PAGE).
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline.
Storage
Store undiluted at 4°C. Do not freeze!
General Notes
Mouse anti Human CD11a antibody, clone MEM-25 recognizes the integrin alphaL subunit, a 170-180 kDa type I transmembrane glycoprotein that associates with CD18 to form the leucocyte function-associated antigen-1, an alphaLbeta2 integrin expressed at the surface of all human leukocyte.LFA-1 is a receptor for ICAMs, JAM-1 and F11R. Its interaction with endothelial ligands, such as ICAM-1 and JAM-1 is responsible for leukocyte arrest and extravasation (Osterman et al.2002). In addition to its role in leukocyte adhesion and transmigration, LFA-1 is involved in T cell differentiation (Verma et al. 2016, Verman and Kelleher 2017) and is required for the effective lysis of infected cells by cytotoxic T cells (Anikeeva et al. 2005, Pontes Ferreira et al. 2017). LFA-1 also contributes to NK cell cytotoxicity (Domingo et al. 2004) and participates to the clearance of apoptotic neutrophils by macrophages (Kristóf et al. 2013). The interaction of LFA-1 with ICAM-1 is the target of Lifitegrast, a drug approved for the treatment of Dry Eye Disease (Abidi et al. 2016).Mouse anti Human CD11 antibody, clone MEM-25 inhibits the cytotoxic activity of NK cells (Bazil et al. 1990).
Synonyms
Antigen CD11A, Antigen CD11A (p180), lymphocyte function associated antigen 1, alpha polypeptide, CD 11a, CD11 antigen-like family member A, CD11a antigen, Integrin Alpha L, Integrin alpha-L, Integrin gene promoter, Integrin, alpha L (antigen CD11A (p180), lymphocyte function associated antigen 1; alpha polypeptide), ITAL_HUMAN, Itgal, ITGAL protein, Leukocyte adhesion glycoprotein LFA 1 alpha chain, Leukocyte adhesion glycoprotein LFA-1 alpha chain, Leukocyte Adhesion Glycoprotein LFA1 Alpha Chain, Leukocyte function associated molecule 1 alpha chain, Leukocyte function-associated molecule 1 alpha chain, LFA 1, LFA 1 alpha, LFA 1 alpha (LFA1A), LFA 1A, LFA-1A, LFA1A, Ly15, Ly21, Lymphocyte function associated antigen 1, Lymphocyte Function Associated Antigen Type 1 alpha, Lymphocyte function associated antigen, type 1, alpha subunit, lymphocyte function-associated antigen 1, alpha polypeptide, p180
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
Publishing research using Anti-CD11a Antibody [MEM-25] (A281135)? Please let us know so that we can list the citation on this page.

Alternative products to Anti-CD11a Antibody [MEM-25] (A281135)

Top