Anti-CCR7 Antibody [4B12] (PE) (A279345)

Anti-CCR7 Antibody [4B12] (PE)

Rat monoclonal [4B12] antibody to CCR7 (PE).

This antibody recognises mouse C-C chemokine receptor type 7, also known as CD197, Epstein-Barr virus-induced G-protein coupled receptor 1, CCR7 or MIP-3 beta receptor. CD197 is a 354 amino acid ~43 kDa member of the G-protein coupled receptor family. In mice, CD197 is expressed on most naïve T cells, a subset of memory T cells, B cells, mature dendritic cells, NK cells, a subset of thymocytes and CD34+ macrophage progenitor cells.CD197 is a functional receptor for chemokines CCL21 and CCL19. The receptor plays an important role in regulating the trafficking and homing of lymphocytes and dendritic cells to secondary lymphoid organs.Rat anti Mouse CD197 antibody, clone 4B12 does not block the binding of the ligand to CD197.

Flow Cytometry: Neat, Use 20µl of the suggested working dilution to label 10⁶ cells in 100µl. The Fc region of monoclonal antibodies may bind to cells expressing low affinity Fc receptors. This may be reduced by using SeroBlock FcR (BUF041A/BUF041B).

Mouse

CCR7 rat basophilic leukaemia (RBL)-2H3 transfectants.

Rat

Monoclonal

4B12

IgG2a

PE

Excitation: 565nm, Emission: 578nm

Reconstitution dependent.

Lyophilized

Reconstitute with 1 ml of distilled water.

Supplied in Phosphate Buffered Saline with 1% BSA, 5% Sucrose, and 0.09% Sodium Azide.

Store undiluted at 4°C. Do not freeze! This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.

Rat anti Mouse CD197 antibody, clone 4B12 recognizes murine C-C chemokine receptor type 7, also known as CD197, Epstein-Barr virus-induced G-protein coupled receptor 1, CCR7 or MIP-3 beta receptor. CD197 is a 354 amino acid ~43 kDa member of the G-protein coupled receptor family. In mice, CD197 is expressed on most naïve T cells, a subset of memory T cells, B cells, mature dendritic cells, NK cells, a subset of thymocytes and CD34+ macrophage progenitor cells.CD197 is a functional receptor for chemokines CCL21 and CCL19. The receptor plays an important role in regulating the trafficking and homing of lymphocytes and dendritic cells to secondary lymphoid organs.Rat anti Mouse CD197 antibody, clone 4B12 does not block the binding of the ligand to CD197.

BLR 2, BLR2, C C chemokine receptor type 7, C C CKR 7, C-C chemokine receptor type 7, C-C CKR-7, CC chemokine receptor 7, CC chemokine receptor type 7, CC CKR 7, CC-CKR-7, CCCKR7, CCR 7, CCR-7, CCR7_HUMAN, CD 197, CD197, CD197 antigen, CDw197, Chemokine (C C motif) receptor 7, Chemokine (C C) receptor 7, Chemokine C C motif receptor 7, Chemokine C C receptor 7, Chemokine receptor 7, Chemokine receptor 7-like protein, CMKBR7, EBI 1, EBI1, Ebi1h, EBV Induced G Protein Coupled Receptor 1, EBV-induced G-protein coupled receptor 1, Epstein Barr virus induced G protein coupled receptor, Epstein Barr virus induced gene 1, Epstein-Barr virus-induced G-protein coupled receptor 1, EVI 1, EVI1, Lymphocyte Specific G Protein Coupled Peptide Receptor, MGC108519, MIP 3 beta receptor, MIP-3 beta receptor, MIP3 Beta Receptor

This product is for research use only. It is not intended for diagnostic or therapeutic use.