Anti-CBL Antibody (A283423)

Anti-CBL Antibody

Rabbit polyclonal antibody to CBL.

This antibody recognises the Casitas B-lineage lymphoma (CBL) E3 ubiquitin ligase, also known as c-CBL proto-oncogene and ring finger protein 55. As the name implies, the viral form of CBL, v-CBL, has been shown to induce lymphoma and leukemia in mice. The CBL protein is a RING finger E3-ubiquitin ligase that plays a key role in signal transduction processes through mediating monoubiquitination and thereby endocytosis of receptor tyrosine kinases (Haglund et al. 2002, Dikic and Giordano 2003). In addition to this role, CBL has also been reported to act as an adaptor protein as well as a mediator of cell signaling processes by changing the cellular localization of substrates.

WB: 1:200

Human, Mouse, Rat

A peptide corresponding to the C-terminus of human E3 ubiquitin-protein ligase CBL.

Rabbit

Polyclonal

IgG

Unconjugated

Affinity chromatography.

Approximately 117 kDa when run under reducing conditions

Liquid

Supplied in Phosphate Buffered Saline with 0.2% Gelatin and 0.1% Sodium Azide.

Store undiluted at 4°C. Do not freeze! Should this product contain a precipitate we recommend microcentrifugation before use.

Rabbit anti E3 ubiquitin-protein ligase CBL antibody recognizes the Casitas B-lineage lymphoma (CBL) E3 ubiquitin ligase, also known as c-CBL proto-oncogene and ring finger protein 55. As the name implies, the viral form of CBL, v-CBL, has been shown to induce lymphoma and leukemia in mice (de Jong et al. 1995).The CBL protein is a RING finger E3-ubiquitin ligase that plays a key role in signal transduction processes through mediating monoubiquitination and thereby endocytosis of receptor tyrosine kinases (Haglund et al. 2002, Dikic and Giordano 2003). In addition to this role, CBL has also been reported to act as an adaptor protein as well as a mediator of cell signaling processes by changing the cellular localization of substrates (Liyasova et al. 2015).

4732447J05Rik, C CBL, Cas Br M (murine) ecotropic retroviral transforming sequence, Casitas B lineage lymphoma proto oncogene, Casitas B-lineage lymphoma proto-oncogene, CBL 2, CBL2, CBL_HUMAN, E3 ubiquitin protein ligase CBL, E3 ubiquitin-protein ligase CBL, Oncogene CBL2, Proto oncogene c CBL, Proto-oncogene c-CBL, RGD1561386, RING finger protein 55, RNF55, Signal transduction protein CBL