Anti-Von Willebrand Factor Antibody [VWF/4458] (A315789)

Anti-Von Willebrand Factor Antibody [VWF/4458]

Mouse monoclonal [VWF/4458] antibody to Von Willebrand Factor.

von Willebrand Factor (vWF) is a multimeric glycoprotein that is found in endothelial cells, plasma and platelets. It acts as a carrier protein for Factor VIII and promotes platelet adhesion and aggregation. vWF undergoes a variety of posttranslational modifications that influence the affinity and availability for Factor VIII, including cleavage of the propeptide and formation of N-terminal disulfide bonds. This antibody helps to establish the endothelial nature of some lesions of disputed histogenesis, e.g. Kaposi s sarcoma and cardiac myxoma. It is widely used for differentiating vascular lesions from those of other tissue differentiation within a panel of other vascular markers although not all tumors of endothelial differentiation contain this antigen.

HUVEC cells. Human tonsil.

IHC: 1-2 µg/ml

Human

Recombinant full-length human VWF. The exact sequence is proprietary.

Mouse

Monoclonal

VWF/4458

Protein A/G chromatography.

200 µg/ml

250 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

F8VWF