Anti-VMAT2 Antibody [SLC18A2/7983] (A315785)

Anti-VMAT2 Antibody [SLC18A2/7983]

Mouse monoclonal [SLC18A2/7983] antibody to VMAT2.

Neurotransmission depends on the regulated exocytotic release of chemical transmitter molecules. This requires the packaging of these substances into the specialized secretory vesicles of neurons and neuroendocrine cells, a process mediated by specific vesicular transporters. The family of genes encoding the vesicular transporters of monoamines (VMAT 1 and VMAT 2) and acetylcholine (VACht) have been cloned and functionally characterized. The sequence of these integral membrane proteins predicts twelve transmembrane domains and weak homology to a class of bacterial antibiotic resistance proteins. The vesicular transport of neurotransmitter molecules has been shown to be an active ATP- and proton dependent transport mechanism.

Human brain, adrenal gland or tonsil.

IHC: 1-2 µg/ml

Human

Recombinant fragment of human SLC18A2 protein. The exact sequence is proprietary.

Mouse

Monoclonal

SLC18A2/7983

kappa

Protein A/G chromatography.

200 µg/ml

63 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Monoamine transporter, SLC18A2, Solute carrier family 18 member 2, SVMT, Synaptic vesicular amine transporter, VAT2, Vesicular amine transporter 2