Anti-VEGFA Antibody [4B2-8] - BSA and Azide free (A279349)

Anti-VEGFA Antibody [4B2-8] - BSA and Azide free

Mouse monoclonal [4B2-8] antibody to VEGFA.

This antibody recognises human Vascular endothelial growth factor A , also known as VEGF-A or Vascular permeability factor. VEGF-A is a 206 amino acid ~45 kDa disulphide linked homodimeric heparin-binding cytokine and member of the PDGF/VEGF growth factor family, which exists as several splice variants of the VEGF gene, and is a potent stimulator of angiogenesis of both normal and cancerous cells, and acts as a regulator of vasculogenesis.The functional forms of VEGF are classified according to the number of amino acid residues within a constitutive polypeptide chain e.g VEGF165, and all VEGF family members act through binding to the tyrosine kinase receptors VEGFR-1 (Flt-1) and VEGFR-2 (KDR/CD309), whilst the closely-related VEGF-C and VEGF-D, can also bind to VEGFR-3 (Flt-4).

WB, ELISA, Functional Assays

ELISA: 2.0 - 4.0 µg/ml, Functional Assays: 0.1 - 0.2 µg/ml, WB: 0.25 - 0.50 µg/ml

Human

Highly purified recombinant human VEGF165.

Mouse

Monoclonal

4B2-8

IgG1

Protein A affinity chromatography of tissue culture supernatant.

Approximately 38.2 kDa using recombinant human VEGF165 PHP091 under non-reducing conditions.

Lyophilized

Reconstitute with 0.5 ml of distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. Gently mix after reconstitution.

Supplied in Phosphate Buffered Saline.

Lyophilized: Store at -20°C. Reconstituted: Store undiluted at -20°C, avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

Mouse anti Human Vascular endothelial growth factor antibody, clone 4B2-8 recognizes human Vascular endothelial growth factor A , also known as VEGF-A or Vascular permeability factor. VEGF-A is a 206 amino acid ~45 kDa disulphide linked homodimeric heparin-binding cytokine and member of the PDGF/VEGF growth factor family, which exists as several splice variants of the VEGF gene, and is a potent stimulator of angiogenesis of both normal and cancerous cells, and acts as a regulator of vasculogenesis.The functional forms of VEGF are classified according to the number of amino acid residues within a constitutive polypeptide chain e.g VEGF165, and all VEGF family members act through binding to the tyrosine kinase receptors VEGFR-1 (Flt-1) and VEGFR-2 (KDR/CD309), whilst the closely-related VEGF-C and VEGF-D, can also bind to VEGFR-3 (Flt-4).

L-VEGF, Vascular endothelial growth factor A, long form, Vascular permeability factor, VEGF, VPF