Anti-VEGF Receptor 2 Antibody [DC101] - BSA and Azide free (A254014)

Anti-VEGF Receptor 2 Antibody [DC101] - BSA and Azide free

Rat monoclonal [DC101] antibody to VEGF Receptor 2.

This antibody is specific to Mouse VEGFR2/FLK-1/CD309 and does not cross-react with FLK-2. VEGFR2 is a type I transmembrane glycoprotein. It is a member of the CSF-1/PDGF receptor family of type III tyrosine kinase receptors. Endothelial cells, embryonic tissues, and megakaryocytes mainly express VEGFR2. It plays an important role in the regulation of angiogenesis, vasculogenesis, and vascular permeability. The ligands of VEGFR2 include VEGF-A, VEGF-C, VEGF-D, and VEGF splice isoforms. Ligation of VEGFR2 with its ligands results in the receptor dimerization and auto-phosphorylation, stimulating endothelial cell proliferation and migration.

WB, Neutralization Studies

WB (non-reducing): 2-5 µg/ml

Mouse

Recombinant full-length mouse VEGFR2 protein.

Rat

Monoclonal

DC101

IgG1

Protein A/G chromatography.

1 mg/ml

180-190 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

CD309, Fetal liver kinase 1, FLK-1, FLK1, KDR, Kinase insert domain receptor, Protein-tyrosine kinase receptor flk-1, Vascular endothelial growth factor receptor 2, VEGFR-2, VEGFR2