Anti-VEGF Receptor 1 Antibody [FLT1/1663] (A277611)

Anti-VEGF Receptor 1 Antibody [FLT1/1663]

Mouse monoclonal [FLT1/1663] antibody to VEGF Receptor 1.

Three cell membrane receptor tyrosine kinases, Flt-1 (also designated VEGF-R1), Flk-1 (also designated VEGF-R2) and Flt-4, putatively involved in the growth of endothelial cells, are characterized by the presence of seven immunoglobulin-like sequences in their extracellular domain. These receptors exhibit high degrees of sequence relatedness to each other as well as lesser degrees of relatedness to the class III receptors including CSF-1/Fms, PDGR, SLFR/Kit and Flt-3/Flk-2. Two members of this receptor class, Flt-1 and Flk-1, have been shown to represent high affinity receptors for vascular endothelial growth factors (VEGFs). On the basis of structural similarity to Flt-1 and Flk-1, it has been speculated that Flt-4 might represent a third receptor for either VEGF or a VEGF-related ligand.

Flow Cytometry, IF, Functional Studies

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml

Human

Recombinant full-length human VEGF-R1 protein.

Mouse

Monoclonal

FLT1/1663

IgG1

kappa

Protein A/G chromatography.

200 µg/ml

150-180 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-VEGF Receptor 1 Antibody [FLT1/1663] - BSA and Azide free (A278199).

FLT, FLT-1, FLT1, Fms-like tyrosine kinase 1, FRT, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, Vascular endothelial growth factor receptor 1, Vascular permeability factor receptor, VEGFR-1, VEGFR1