Anti-VCAM1 Antibody [MR106] (A281273)

Anti-VCAM1 Antibody [MR106]

Mouse monoclonal [MR106] antibody to VCAM1.

This antibody recognises rat CD106, otherwise known as VCAM-1 (vascular adhesion molecule 1), a 110kDa inducible type I transmembrane glycoprotein and member of the immunoglobulin supergene family, which is predominantly expressed on vascular endothelium, and also on bone marrow stromal cells, follicular dendritic cells and some macrophages.CD106 interacts with the lymphocyte homing receptor VLA-4 (alpha4 beta1 integrin) and LPAM-1 (alpha4 beta7 integrin) and mediates leucocyte-endothelial cell adhesion and signal transduction. Expression of CD106 is upregulated following cytokine activation, and endothelial CD106 plays a role in the extravasation of leucocytes from blood vessels during inflammation.

Flow Cytometry, IHC-Fr, IF

Flow Cytometry: Neat - 1:25, Use 10µl of the suggested working dilution to label 1x10⁶ cells in 100µl.

Rat

Rat CD106-transfected L5178Y cells.

Mouse

Monoclonal

MR106

IgG1

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Rat CD106 antibody, clone MR106 recognizes rat CD106, otherwise known as VCAM-1 (vascular adhesion molecule 1), a 110kDa inducible type I transmembrane glycoprotein and member of the immunoglobulin supergene family, which is predominantly expressed on vascular endothelium, and also on bone marrow stromal cells, follicular dendritic cells and some macrophages.CD106 interacts with the lymphocyte homing receptor VLA-4 (alpha4 beta1 integrin) and LPAM-1 (alpha4 beta7 integrin) and mediates leucocyte-endothelial cell adhesion and signal transduction. Expression of CD106 is upregulated following cytokine activation, and endothelial CD106 plays a role in the extravasation of leucocytes from blood vessels during inflammation.

CD106, INCAM-100, V-CAM 1, Vascular cell adhesion protein 1, VCAM-1