Anti-Ubiquitin Antibody [UBB/2122] (A250262)

Mouse monoclonal [UBB/2122] antibody to Ubiquitin for ELISA, WB and IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Shipping Information

$40
Dispatched from St. Louis, MO.
Lead Time: 4-6 business days.
Name
Anti-Ubiquitin Antibody [UBB/2122]
Description
Mouse monoclonal [UBB/2122] antibody to Ubiquitin.
Specificity
Ubiquitin is a highly conserved and plays an essential role in the ubiquitin-proteasome pathway. In ubiquitination process, it is first activated by forming a thiol-ester complex with the activation component E1, which is then transferred to ubiquitin-carrier protein E2, followed by to ubiquitin ligase E3 for final delivery to epsilon-NH2 of the target protein lysine residue. IkB, p53, cdc25A, Bcl-2 etc. are shown as targets of ubiquitin-proteasome process as part of regulation of cell cycle progression, differentiation, cell stress response, and apoptosis. Moreover, ubiquitin have been reported to bind covalently with pathological inclusions which are resistant to degradation e.g. neurofibrillary tangles/paired helical filaments in Alzheimers disease etc.
Applications
ELISA, WB, IHC-P
Dilutions
WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment, around amino acids 1-119, of human Ubiquitin protein. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
UBB/2122
Isotype
IgG1
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
9 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Ubiquitin Antibody [UBB/2122] - BSA and Azide free (A253442).
Synonyms
Polyubiquitin-B, Polyubiquitin-C, UBB, UBC
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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