Anti-TTF1 Antibody [TTF1/8427] (A315767)

Anti-TTF1 Antibody [TTF1/8427]

Mouse monoclonal [TTF1/8427] antibody to TTF1.

Recognizes a protein of 40kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates.Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.

MAD109, MLE-15, H441-4, or H345 cells. Normal thyroid or lung.

IHC: 1-2 µg/ml

Human

Recombinant human TTF-1 protein.

Mouse

Monoclonal

TTF1/8427

kappa

Protein A/G chromatography.

200 µg/ml

40 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Homeobox protein NK-2 homolog A, Homeobox protein Nkx-2.1, NKX2-1, NKX2A, T/EBP, Thyroid nuclear factor 1, Thyroid transcription factor 1, Thyroid-specific enhancer-binding protein, TITF1, TTF-1